Evidence map›Paper›PMID 39026855›Full record

ArticlebioRxiv : the preprint server for biology2024

A dendritic substrate for temporal diversity of cortical inhibition.

Annunziato Morabito, Yann Zerlau, Dhanasak Dhanasobhon, Emmanuelle Berthaux, Alexandra Tzilivaki, Gael Moneron, Laurence Cathala, Panayiota Poirazi, Alberto Bacci, David DiGregorio and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Annunziato MorabitoICM, Paris Brain Institute, Hôpital de la Pitié-Salpêtrière, Sorbonne Université, Inserm, CNRS, Paris, 75013, France.
Yann ZerlauICM, Paris Brain Institute, Hôpital de la Pitié-Salpêtrière, Sorbonne Université, Inserm, CNRS, Paris, 75013, France.
Dhanasak DhanasobhonICM, Paris Brain Institute, Hôpital de la Pitié-Salpêtrière, Sorbonne Université, Inserm, CNRS, Paris, 75013, France.
Emmanuelle BerthauxICM, Paris Brain Institute, Hôpital de la Pitié-Salpêtrière, Sorbonne Université, Inserm, CNRS, Paris, 75013, France.
Alexandra TzilivakiCharité-Universitätsmedizin Berlin, corporate member of Freie Universität zu Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Neuroscience Research Center, 10117 Berlin, Germany.
Gael MoneronInstitut Pasteur, CNRS UMR3571, Synapse and Circuit Dynamics Unit, 75015 Paris, France.
Laurence CathalaICM, Paris Brain Institute, Hôpital de la Pitié-Salpêtrière, Sorbonne Université, Inserm, CNRS, Paris, 75013, France.
Panayiota PoiraziInstitute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology Hellas (FORTH), Heraklion, 70013, Greece.
Alberto BacciICM, Paris Brain Institute, Hôpital de la Pitié-Salpêtrière, Sorbonne Université, Inserm, CNRS, Paris, 75013, France.
David DiGregorioInstitut Pasteur, CNRS UMR3571, Synapse and Circuit Dynamics Unit, 75015 Paris, France.
Joana LourençoICM, Paris Brain Institute, Hôpital de la Pitié-Salpêtrière, Sorbonne Université, Inserm, CNRS, Paris, 75013, France.
Nelson RebolaICM, Paris Brain Institute, Hôpital de la Pitié-Salpêtrière, Sorbonne Université, Inserm, CNRS, Paris, 75013, France.

Funding

Experimental and modeling investigations into microcircuit, cellular and subcellular determinants of hippocampal ensemble recruitment to contextual representationsR01MH124867 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LOSONCZY, ATTILA, POIRAZI, PANAYIOTA · 2021 to 2025
$3.4M
NIMH NIH HHS R01 MH124867
6 · The paper itself

Abstract

In the mammalian neocortex, GABAergic interneurons (INs) inhibit cortical networks in profoundly different ways. The extent to which this depends on how different INs process excitatory signals along their dendrites is poorly understood. Here, we reveal that the functional specialization of two major populations of cortical INs is determined by the unique association of different dendritic integration modes with distinct synaptic organization motifs. We found that somatostatin (SST)-INs exhibit NMDAR-dependent dendritic integration and uniform synapse density along the dendritic tree. In contrast, dendrites of parvalbumin (PV)-INs exhibit passive synaptic integration coupled with proximally enriched synaptic distributions. Theoretical analysis shows that these two dendritic configurations result in different strategies to optimize synaptic efficacy in thin dendritic structures. Yet, the two configurations lead to distinct temporal engagement of each IN during network activity. We confirmed these predictions with

Identifiers

PMID39026855
PMCPMC11257522

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.