Evidence map›Paper›PMID 39026854›Full record

ArticlebioRxiv : the preprint server for biology2024

Vestigial like 4 regulates the adipogenesis of classical brown adipose tissue.

Pingzhu Zhou, Chase W Kessinger, Fei Gu, Amanda Davenport, Justin S King, Genyu Wang, Steven G Negron, Bart Deplancke, William T Pu, Zhiqiang Lin

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pingzhu ZhouBoston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115.
Chase W KessingerDepartment of Biomedical Research and Translational Medicine, Masonic Medical Research Institute, 2150 Bleecker St, Utica, NY 13501.
Fei GuBoston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115.
Amanda DavenportDepartment of Biomedical Research and Translational Medicine, Masonic Medical Research Institute, 2150 Bleecker St, Utica, NY 13501.
Justin S KingBoston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115.
Genyu WangDepartment of Biomedical Research and Translational Medicine, Masonic Medical Research Institute, 2150 Bleecker St, Utica, NY 13501.
Steven G NegronDepartment of Biomedical Research and Translational Medicine, Masonic Medical Research Institute, 2150 Bleecker St, Utica, NY 13501.
Bart DeplanckeSwiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland.
William T PuBoston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115.
Zhiqiang LinDepartment of Biomedical Research and Translational Medicine, Masonic Medical Research Institute, 2150 Bleecker St, Utica, NY 13501.

Funding

YAP and IRF2BP2 regulation of cardiomyocyte innate immune responsesR01HL146810 · NHLBI · MASONIC MEDICAL RESEARCH LABORATORY, INC · PI Zhiqiang Lin · 2022 to 2026
$3.2M
YAP1 Regulation of cardiomyocyte proliferation, function, and regenerationR01HL116461 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI PU, WILLIAM TSWENCHING · 2013 to 2017
$2.6M
Regulation of Cardiomyocyte MaturationR01HL146634 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI PU, WILLIAM TSWENCHING · 2019 to 2022
$2.4M
VGLL4 and IRF2BP2 regulation of cardiomyocyte survival and hypertrophyR56HL138454 · NHLBI · MASONIC MEDICAL RESEARCH LABORATORY, INC · PI LIN, ZHIQIANG · 2017 to 2017
$443k
NHLBI NIH HHS R01 HL116461NHLBI NIH HHS R01 HL146634NHLBI NIH HHS R01 HL146810NHLBI NIH HHS R56 HL138454
6 · The paper itself

Abstract

Brown adipose tissue (BAT) is mammals' primary non-shivering thermogenesis organ, and the molecular mechanisms regulating BAT growth and adipogenesis are largely unknown. The Hippo-YAP pathway has been well-known for controlling organ size, and Vestigial like 4 (VGLL4) is a transcriptional regulator that modulates the Hippo-YAP pathway by competing against YAP for binding to TEAD proteins. In this study, we dissected the function of VGLL4 in regulating BAT development. We generated a conventional

Indexed as

adipogenesisCEBPβclassical brown adipose tissuedevelopmentHippo-YAP pathwayTEAD1Vestigial like 4

Identifiers

PMID39026854
PMCPMC11257599

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.