ArticlebioRxiv : the preprint server for biology2024
eIF1 and eIF5 dynamically control translation start site fidelity.
Rosslyn Grosely, Carlos Alvarado, Ivaylo P Ivanov, Oliver B Nicholson, Joseph D Puglisi, Thomas E Dever, Christopher P Lapointe
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
7 authors.
Rosslyn GroselyDept. of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.
Carlos AlvaradoDept. of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.
Ivaylo P IvanovEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Oliver B NicholsonBasic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Joseph D PuglisiDept. of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.
Thomas E DeverEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Funding
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4MMechanism and Regulation of Eukaryotic Protein SynthesisZIAHD001010 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI DEVER, THOMAS E · 2009 to 2025
$29.4MDynamics of TranslationR35GM145306 · NIGMS · STANFORD UNIVERSITY · PI JOSEPH D PUGLISI · 2022 to 2026
$3.8MDefining modifiers and mechanisms of RAN translationRF1AG064690 · NIA · STANFORD UNIVERSITY · PI GITLER, AARON D., PUGLISI, JOSEPH D · 2019 to 2019
$2.8MDefining modifiers and mechanisms of RAN translationR01AG064690 · NIA · STANFORD UNIVERSITY · PI Aaron D. Gitler, JOSEPH D PUGLISI · 2024 to 2026
$2.3MFrom one end to the other: dynamics of human translation initiation and its controlR00GM144678 · NIGMS · FRED HUTCHINSON CANCER CENTER · PI LAPOINTE, CHRISTOPHER PAUL · 2023 to 2024
$498kNCI NIH HHS P30 CA015704NIA NIH HHS R01 AG064690NIA NIH HHS RF1 AG064690NIGMS NIH HHS R00 GM144678NIGMS NIH HHS R35 GM145306
6 · The paper itselfAbstract
Translation initiation defines the identity of a synthesized protein through selection of a translation start site on a messenger RNA. This process is essential to well-controlled protein synthesis, modulated by stress responses, and dysregulated in many human diseases. The eukaryotic initiation factors eIF1 and eIF5 interact with the initiator methionyl-tRNA
Identifiers
PMID39026837
PMCPMC11257575
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