Evidence map›Paper›PMID 39026825›Full record

ArticlebioRxiv : the preprint server for biology2024

A Retinoic Acid:YAP1 signaling axis controls atrial lineage commitment.

Elizabeth Abraham, Brett Volmert, Thomas Roule, Ling Huang, Jingting Yu, April E Williams, Henry M Cohen, Aidan Douglas, Emily Megill, Alex Morris and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Elizabeth AbrahamDepartment of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Temple University, Lewis Katz School of Medicine, Philadelphia, PA, USA.
Brett VolmertInstitute for Quantitative Health Science and Engineering, Division of Developmental and Stem Cell Biology, Michigan State University, East Lansing, MI, USA.
Thomas RouleRaymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Ling HuangIntegrative Genomics and Bioinformatics Core, Salk Institute for Biological Studies, La Jolla, CA, USA.
Jingting YuIntegrative Genomics and Bioinformatics Core, Salk Institute for Biological Studies, La Jolla, CA, USA.
April E WilliamsIntegrative Genomics and Bioinformatics Core, Salk Institute for Biological Studies, La Jolla, CA, USA.
Henry M CohenDepartment of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Temple University, Lewis Katz School of Medicine, Philadelphia, PA, USA.
Aidan DouglasDepartment of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Temple University, Lewis Katz School of Medicine, Philadelphia, PA, USA.
Emily MegillDepartment of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Temple University, Lewis Katz School of Medicine, Philadelphia, PA, USA.
Alex MorrisDepartment of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Temple University, Lewis Katz School of Medicine, Philadelphia, PA, USA.
Eleonora StronatiDepartment of Child and Adolescence Psychiatry, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Raquel FueyoDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.
Mikel ZubillagaDepartment of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Temple University, Lewis Katz School of Medicine, Philadelphia, PA, USA.
John W ElrodDepartment of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Temple University, Lewis Katz School of Medicine, Philadelphia, PA, USA.
Naiara AkizuRaymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Aitor AguirreInstitute for Quantitative Health Science and Engineering, Division of Developmental and Stem Cell Biology, Michigan State University, East Lansing, MI, USA.
Conchi EstarasDepartment of Cardiovascular Sciences, Aging + Cardiovascular Discovery Center, Temple University, Lewis Katz School of Medicine, Philadelphia, PA, USA.

Funding

Integrative Cardiovascular PathophysiologyT32HL091804 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2008 to 2024
$4.5M
Oxylipin Signaling in Congenital Heart DiseaseR01HL151505 · NHLBI · MICHIGAN STATE UNIVERSITY · PI AGUIRRE, AITOR · 2021 to 2025
$2.2M
The Role of Hippo-Yap1 Signaling in Germ-layer SpecificationR01HD106969 · NICHD · TEMPLE UNIV OF THE COMMONWEALTH · PI Concepcion Estaras · 2022 to 2026
$2.1M
Lipid signaling in cardiac development and diseaseK01HL135464 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AGUIRRE, AITOR · 2017 to 2021
$795k
The Role of YAP1:TEAD Enhancers in the Retinoic Acid-Regulatory Network of Cardiac ProgenitorsR56HL163146 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ESTARAS, CONCEPCION · 2022 to 2022
$469k
NHLBI NIH HHS K01 HL135464NHLBI NIH HHS R01 HL151505NHLBI NIH HHS R56 HL163146NHLBI NIH HHS T32 HL091804NICHD NIH HHS R01 HD106969
6 · The paper itself

Abstract

Vitamin A/Retinoic Acid (Vit A/RA) signaling is essential for heart development. In cardiac progenitor cells (CPCs), RA signaling induces the expression of atrial lineage genes while repressing ventricular genes, thereby promoting the acquisition of an atrial cardiomyocyte cell fate. To achieve this, RA coordinates a complex regulatory network of downstream effectors that is not fully identified. To address this gap, we applied a functional genomics approach (i.e scRNAseq and snATACseq) to untreated and RA-treated human embryonic stem cells (hESCs)-derived CPCs. Unbiased analysis revealed that the Hippo effectors YAP1 and TEAD4 are integrated with the atrial transcription factor enhancer network, and that YAP1 is necessary for activation of RA-enhancers in CPCs. Furthermore, in vivo analysis of control and conditionally YAP1 KO mouse embryos (

Identifiers

PMID39026825
PMCPMC11257518

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.