Evidence map›Paper›PMID 39026799›Full record

ArticlebioRxiv : the preprint server for biology2024

Structurally targeted mutagenesis identifies key residues supporting

Patricia M Reis, Sara A M Holec, Chimere Ezeiruaku, Matthew P Frost, Christine K Brown, Samantha L Liu, Steven H Olson, Amanda L Woerman

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Patricia M ReisDepartment of Biology and Institute for Applied Life Sciences, University of Massachusetts Amherst, Amherst, MA, USA.
Sara A M HolecDepartment of Biology and Institute for Applied Life Sciences, University of Massachusetts Amherst, Amherst, MA, USA.
Chimere EzeiruakuDepartment of Biology and Institute for Applied Life Sciences, University of Massachusetts Amherst, Amherst, MA, USA.
Matthew P FrostDepartment of Biology and Institute for Applied Life Sciences, University of Massachusetts Amherst, Amherst, MA, USA.ORCID 0000-0002-9973-2572
Christine K BrownDepartment of Biology and Institute for Applied Life Sciences, University of Massachusetts Amherst, Amherst, MA, USA.
Samantha L LiuDepartment of Biology and Institute for Applied Life Sciences, University of Massachusetts Amherst, Amherst, MA, USA.
Steven H OlsonConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA, USA.
Amanda L WoermanDepartment of Biology and Institute for Applied Life Sciences, University of Massachusetts Amherst, Amherst, MA, USA.ORCID 0000-0003-4029-1968

Funding

Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI STEVEN E ARNOLD · 2019 to 2026
$36.5M
Effect of Agent and Host Factors on Alpha-Synuclein Strain PathogenesisR01NS121294 · NINDS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Amanda L. Woerman · 2022 to 2026
$2.9M
A Novel Gene Therapy Approach to Prevent Alpha-synuclein Misfolding in Multiple System AtrophyR21NS127002 · NINDS · COLORADO STATE UNIVERSITY · PI WOERMAN, AMANDA L. · 2023 to 2024
$422k
NIA NIH HHS P30 AG062421NINDS NIH HHS R01 NS121294NINDS NIH HHS R21 NS127002
6 · The paper itself

Abstract

Multiple system atrophy (MSA) and Parkinson's disease (PD) are caused by misfolded

Identifiers

PMID39026799
PMCPMC11257492

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.