Evidence map›Paper›PMID 39026762›Full record

ArticlebioRxiv : the preprint server for biology2024

Epigenetic regulation by TET1 in gene-environmental interactions influencing susceptibility to congenital malformations.

Bernard K van der Veer, Lehua Chen, Spyridon Champeris Tsaniras, Wannes Brangers, Qiuying Chen, Mariana Schroiff, Colin Custers, Harm H M Kwak, Rita Khoueiry, Robert Cabrera and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Bernard K van der VeerDepartment of Development and Regeneration, Laboratory of Stem Cell and Developmental Epigenetics, KU Leuven, Leuven 3000, Belgium.
Lehua ChenDepartment of Development and Regeneration, Laboratory of Stem Cell and Developmental Epigenetics, KU Leuven, Leuven 3000, Belgium.
Spyridon Champeris TsanirasDepartment of Development and Regeneration, Laboratory of Stem Cell and Developmental Epigenetics, KU Leuven, Leuven 3000, Belgium.
Wannes BrangersDepartment of Development and Regeneration, Laboratory of Stem Cell and Developmental Epigenetics, KU Leuven, Leuven 3000, Belgium.
Qiuying ChenDepartment of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA.ORCID 0000-0001-5909-3959
Mariana SchroiffDepartment of Development and Regeneration, Laboratory of Stem Cell and Developmental Epigenetics, KU Leuven, Leuven 3000, Belgium.
Colin CustersDepartment of Development and Regeneration, Laboratory of Stem Cell and Developmental Epigenetics, KU Leuven, Leuven 3000, Belgium.
Harm H M KwakDepartment of Development and Regeneration, Laboratory of Stem Cell and Developmental Epigenetics, KU Leuven, Leuven 3000, Belgium.
Rita KhoueiryDepartment of Development and Regeneration, Laboratory of Stem Cell and Developmental Epigenetics, KU Leuven, Leuven 3000, Belgium.
Robert CabreraDepartment of Molecular and Cellular Biology, Center for Precision Environmental Health, Baylor College of Medicine, Houston, Texas, USA.
Steven S GrossDepartment of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA.
Richard H FinnellDepartment of Molecular and Cellular Biology, Center for Precision Environmental Health, Baylor College of Medicine, Houston, Texas, USA.
Yunping LeiDepartment of Molecular and Cellular Biology, Center for Precision Environmental Health, Baylor College of Medicine, Houston, Texas, USA.
Kian Peng KohDepartment of Development and Regeneration, Laboratory of Stem Cell and Developmental Epigenetics, KU Leuven, Leuven 3000, Belgium.

Funding

Role of Slc25a32 and Its Interaction with Lrp6 in the Etiology of Neural Tube DefectsR01HD100535 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI FINNELL, RICHARD H., LEI, YUNPING · 2020 to 2024
$2.9M
NICHD NIH HHS R01 HD100535
6 · The paper itself

Abstract

The etiology of neural tube defects (NTDs) involves complex gene-environmental interactions. Folic acid (FA) prevents NTDs, but the mechanisms remain poorly understood and at least 30% of human NTDs resist the beneficial effects of FA supplementation. Here, we identify the DNA demethylase TET1 as a nexus of folate-dependent one-carbon metabolism and genetic risk factors post-neural tube closure. We determine that cranial NTDs in

Identifiers

PMID39026762
PMCPMC11257484

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.