Evidence map›Paper›PMID 39026652›Full record

ArticleRSC medicinal chemistry2024

Inhibition of DXR in the MEP pathway with lipophilic

Darean Bague, Ruiqin Wang, Dana Hodge, Marwa O Mikati, Jose S Roma, Helena I Boshoff, Allyson L Dailey, Misgina Girma, Robin D Couch, Audrey R Odom John and 1 more

Abstract read
In one paragraph

Article in RSC medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Efficient logRSC medicinal chemistry · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Darean BagueDepartment of Chemistry, George Washington University Washington D.C. 20052 USA cdowd@gwu.edu.
Ruiqin WangDepartment of Chemistry, George Washington University Washington D.C. 20052 USA cdowd@gwu.edu.
Dana HodgeDivision of Infectious Diseases, Children's Hospital of Philadelphia Philadelphia PA 19104 USA.ORCID https://orcid.org/0000-0001-8924-0649
Marwa O MikatiDepartment of Molecular Microbiology, Washington University School of Medicine St. Louis MO 63110 USA.ORCID https://orcid.org/0000-0002-0914-8592
Jose S RomaTuberculosis Research Section, LCIM, NIAID/NIH Bethesda MD 20892 USA.
Helena I BoshoffTuberculosis Research Section, LCIM, NIAID/NIH Bethesda MD 20892 USA.ORCID https://orcid.org/0000-0002-4333-206X
Allyson L DaileyDepartment of Chemistry and Biochemistry, George Mason University Fairfax VA 22030 USA.
Misgina GirmaDepartment of Chemistry and Biochemistry, George Mason University Fairfax VA 22030 USA.
Robin D CouchDepartment of Chemistry and Biochemistry, George Mason University Fairfax VA 22030 USA.ORCID https://orcid.org/0000-0002-0364-1634
Audrey R Odom JohnDivision of Infectious Diseases, Children's Hospital of Philadelphia Philadelphia PA 19104 USA.ORCID https://orcid.org/0000-0001-8395-8537
Cynthia S DowdDepartment of Chemistry, George Washington University Washington D.C. 20052 USA cdowd@gwu.edu.ORCID https://orcid.org/0000-0001-5011-7029

Funding

Development Of New Chemotherapeutics For TuberculosisZIAAI000693 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BARRY, CLIFTON · 2009 to 2025
$20.1M
MEP pathway resistance in Plasmodium falciparumR01AI103280 · NIAID · WASHINGTON UNIVERSITY · PI Audrey Ragan Odom John · 2013 to 2026
$5.5M
Structure-based microbially targeted prodrugsR01AI171514 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI DOWD, CYNTHIA SCHIECK, JEZ, JOSEPH MARTIN · 2022 to 2025
$4.0M
Inhibition of MEP pathway Isoprenoid BiosynthesisR01AI123433 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI DOWD, CYNTHIA SCHIECK, MEYERS, MARVIN J · 2016 to 2020
$2.6M
TARGETING ISPC TO TREAT MALARIAR21AI123808 · NIAID · WASHINGTON UNIVERSITY · PI ODOM JOHN, AUDREY RAGAN · 2016 to 2017
$440k
NIAID NIH HHS R01 AI103280NIAID NIH HHS R01 AI123433NIAID NIH HHS R01 AI171514NIAID NIH HHS R21 AI123808
6 · The paper itself

Abstract

In

Identifiers

PMID39026652
PMCPMC11253873

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.