Evidence map›Paper›PMID 39026610›Full record

ArticleCurrent addiction reports2023

Sex and Gender Differences in Co-Occurring Alcohol Use Disorder and PTSD.

Tanya C Saraiya, Sudie E Back, Amber M Jarnecke, Shannon M Blakey, Alexandria G Bauer, Delisa G Brown, Lesia M Ruglass, Therese Killeen, Denise A Hien

Abstract read
In one paragraph

Article in Current addiction reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. A whole-brain voxel-based analysis of structural abnormalities in PTSD: An ENIGMA-PGC study.European psychiatry : the journal of the Association of European Psychiatrists · 2025
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tanya C SaraiyaCenter of Alcohol & Substance Use Studies, Rutgers University-New Brunswick, 607 Allison Road, Piscataway, NJ 08854, USA.ORCID 0000-0002-8910-947X
Sudie E BackDepartment of Psychiatry and Behavioral Sciences, College of Medicine, Medical University of South Carolina, 125 Doughty Street, Suite 300, Charleston, SC 29425, USA.
Amber M JarneckeDepartment of Psychiatry and Behavioral Sciences, College of Medicine, Medical University of South Carolina, 125 Doughty Street, Suite 300, Charleston, SC 29425, USA.
Shannon M BlakeyRTI International, Research Triangle Park, NC, USA.
Alexandria G BauerCenter of Alcohol & Substance Use Studies, Rutgers University-New Brunswick, 607 Allison Road, Piscataway, NJ 08854, USA.
Delisa G BrownDepartment of Psychiatry and Behavioral Sciences, College of Medicine, Medical University of South Carolina, 125 Doughty Street, Suite 300, Charleston, SC 29425, USA.
Lesia M RuglassCenter of Alcohol & Substance Use Studies, Rutgers University-New Brunswick, 607 Allison Road, Piscataway, NJ 08854, USA.
Therese KilleenDepartment of Psychiatry and Behavioral Sciences, College of Medicine, Medical University of South Carolina, 125 Doughty Street, Suite 300, Charleston, SC 29425, USA.
Denise A HienCenter of Alcohol & Substance Use Studies, Rutgers University-New Brunswick, 607 Allison Road, Piscataway, NJ 08854, USA.

Funding

The Impact of Stress and Craving on Return to Postpartum Cannabis UseU54DA016511 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI AIMEE L MCRAE-CLARK, Rachel Lynn Tomko · 2018 to 2026
$15.9M
Meta-analysis of Individual Patient Data for PTSD/AODsR01AA025853 · NIAAA · RESEARCH TRIANGLE INSTITUTE · PI HIEN, DENISE AIMEE, MORGAN-LOPEZ, ANTONIO A · 2018 to 2021
$1.7M
Integrated Treatment for Co-Occurring Opioid Use Disorder and Posttraumatic Stress DisorderK23DA055209 · NIDA · RUTGERS, THE STATE UNIV OF N.J. · PI Tanya Chandresh Saraiya · 2022 to 2026
$1.1M
Identifying the neurobehavioral signature of individuals with AUD and comorbid PTSDK23AA027307 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI JARNECKE, AMBER · 2019 to 2023
$1.0M
NIAAA NIH HHS K23 AA027307NIAAA NIH HHS R01 AA025853NIDA NIH HHS K23 DA055209NIDA NIH HHS U54 DA016511
6 · The paper itself

Abstract

Purpose of Review: Research demonstrates a strong association between alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD). However, less is known about sex- and gender-based differences among individuals with AUD + PTSD. This narrative review examines recent literature in this area and aims to be a reference for future research endeavors. Recent Findings: Extant literature shows that intertwining biological systems increase females' risk of developing PTSD and experiencing more adverse effects from AUD compared to males. Sex-based physiological differences further interact with gendered sociocultural environments to influence the risk of AUD + PTSD. Emerging research suggests potential gender-specific pathways between PTSD, coping, and AUD which may inform prevention and treatment. However, barriers to care are often gender-specific and tailored approaches are needed to improve reach and uptake. Summary: Additional research is needed to examine intersectional and contextual factors that synergistically influence sex/gender differences in AUD + PTSD, particularly beyond cisgender identities, and mechanisms of action.

Indexed as

Alcohol use disorderComorbidityGenderPosttraumatic stress disorderSex

Identifiers

PMID39026610
PMCPMC11257080

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.