Evidence map›Paper›PMID 39026517›Full record

ArticleBioMed research international2024

Oncological Outcome of Node-Positive Oral Squamous Cell Carcinomas Treated With Selective and Comprehensive Neck Dissection.

Jan Oliver Voss, Lea Freund, Felix Neumann, Kerstin Rubarth, Kilian Kreutzer, Steffen Sander, Evelyn Golembiewski, Friedrich Mrosk, Christian Doll, Carsten Rendenbach and 2 more

Abstract read
In one paragraph

Article in BioMed research international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jan Oliver VossDepartment of Oral and Maxillofacial Surgery Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin Humboldt-Universität zu Berlin and Berlin Institute of Health, Augustenburger Platz 1 13353, Berlin, Germany.ORCID https://orcid.org/0000-0002-1760-2599
Lea FreundDepartment of Oral and Maxillofacial Surgery Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin Humboldt-Universität zu Berlin and Berlin Institute of Health, Augustenburger Platz 1 13353, Berlin, Germany.
Felix NeumannDepartment of Oral and Maxillofacial Surgery Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin Humboldt-Universität zu Berlin and Berlin Institute of Health, Augustenburger Platz 1 13353, Berlin, Germany.
Kerstin RubarthBerlin Institute of Health (BIH), Anna-Louisa-Karsch-Straße 2 10178, Berlin, Germany.
Kilian KreutzerDepartment of Oral and Maxillofacial Surgery Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin Humboldt-Universität zu Berlin and Berlin Institute of Health, Augustenburger Platz 1 13353, Berlin, Germany.ORCID https://orcid.org/0000-0003-0581-4137
Steffen SanderCharité Comprehensive Cancer Center Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin Humboldt-Universität zu Berlin and Berlin Institute of Health, Virchowweg 23 10117, Berlin, Germany.
Evelyn GolembiewskiDepartment of Radiation Oncology Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin Humboldt-Universität zu Berlin and Berlin Institute of Health, Augustenburger Platz 1 13353, Berlin, Germany.
Friedrich MroskDepartment of Oral and Maxillofacial Surgery Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin Humboldt-Universität zu Berlin and Berlin Institute of Health, Augustenburger Platz 1 13353, Berlin, Germany.
Christian DollDepartment of Oral and Maxillofacial Surgery Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin Humboldt-Universität zu Berlin and Berlin Institute of Health, Augustenburger Platz 1 13353, Berlin, Germany.
Carsten RendenbachDepartment of Oral and Maxillofacial Surgery Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin Humboldt-Universität zu Berlin and Berlin Institute of Health, Augustenburger Platz 1 13353, Berlin, Germany.ORCID https://orcid.org/0000-0002-9565-7640
Max HeilandDepartment of Oral and Maxillofacial Surgery Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin Humboldt-Universität zu Berlin and Berlin Institute of Health, Augustenburger Platz 1 13353, Berlin, Germany.ORCID https://orcid.org/0000-0002-4987-2913
Steffen KoerdtDepartment of Oral and Maxillofacial Surgery Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin Humboldt-Universität zu Berlin and Berlin Institute of Health, Augustenburger Platz 1 13353, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selective neck dissection (SND) is the treatment of choice in patients with oral squamous cell carcinomas (OSCCs) and clinically node-negative necks (cN0). The treatment of patients with positive-staged necks (cN+) includes SND as well as comprehensive neck dissection (CND). The clear benefit of one or the other remains under debate. We aim to address this lack of clarity by analysing patients with OSCC staged with clinically node-positive necks, treated with either CND or SND using a level-by-level approach. This retrospective study included patients diagnosed with OSCC with clinically (cN+) and pathologically (pN+) positive cervical lymph nodes (LNs) with clear neck level categorization during the years 2010-2019. In total, 74 patients were analysed. Cox regression analysis found no significance for the type of ND being an independent risk factor, neither for overall survival (OS) nor for disease-free survival (DFS). Regional recurrence of CND cases (5.77%) was comparable to SND cases (9.09%). For OS, extracapsular spread (ECS) and male sex were identified as independent risk factors with poorer outcome. pT-stage and ECS were found to be independent risk factors for DFS. The results of this study suggest that both CND and SND may be viable treatment options for certain patients with OSCC pN+.

Indexed as

Carcinoma, Squamous CellLymphatic MetastasisLymph NodesMouth NeoplasmsNeck DissectionAdultAgedAged, 80 and overDisease-Free SurvivalFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalRetrospective StudiesRisk Factorscomprehensive neck dissectionhead and neck cancerlymph node metastasesneck dissectionoral squamous cell carcinomaselective neck dissection

Identifiers

PMID39026517
PMCPMC11257757

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.