ArticleThe Journal of clinical endocrinology and metabolism2025
Endogenous Estrogens and Brain Activation During Verbal Memory Encoding and Recognition in the Postmenopause.
Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Estradiol and memory circuitry in the postmenopause: Modification by APOE4.Research square · 2026Article
- Evidence of APOE4-related brain vulnerabilities in verbal memory systems in midlife women.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Estradiol modulated brain connectivity in females during midlife performing an episodic memory task.Brain imaging and behavior · 2026Article
- Loss of ovarian hormones is detrimental in early disease stages of mouse models of Alzheimer's disease and multi-etiology dementia.Biology of sex differences · 2025Article
- Genetic, Epigenetic, and Hormonal Regulation of Stress Phenotypes in Major Depressive Disorder: From Maladaptation to Resilience.Cellular and molecular neurobiology · 2025Review
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6 authors.
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Abstract
contextChanges in verbal memory have been reliably reported across the menopause transition. To understand the role of endogenous estrogens in verbal memory performance, this study assessed the associations of endogenous estradiol and estrone with brain network connectivity during a verbal memory fMRI task.
objectiveDetermine associations of endogenous estrogens with memory systems in the postmenopausal brain and evaluate clinical significance.
methodsIn the MsBrain cohort (n = 199, mean age 59.3 ± 3.9 years, 83.9% White), we examined the cross-sectional association of serum estradiol (E2) and estrone (E1), measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS), during a functional magnetic resonance imaging (fMRI) task of word encoding and recognition. To characterize the clinical significance of those associations, we examined the magnitude of activation in relation to a neuropsychological measures of memory and affect.
resultsEndogenous E2 was positively associated with activation in temporal and frontal cortices during encoding and negatively associated with one prefrontal region during recognition (P < .05). Activation in the left inferior frontal gyrus was associated with memory performance (β [SE] = 0.004 [0.002]; P < .05), and anxiety (β [SE] = -0.100 [0.050]; P < .05). The left middle frontal gyrus was associated with memory performance (β [SE] = 0.006 [0.002]; P < .01), depression, and anxiety. The left superior temporal gyrus (STG) was associated with depression (β [SE] = -0.083 [0.036]; P < .05) and anxiety (β [SE] = -0.134 [0.058]; P < .05). E1 was positively associated with activation in a range of brain areas including bilateral STG and right superior frontal gyrus during encoding (P < .05). Activation of the left insula and precentral gyrus were associated with symptoms of depression and anxiety. None related to memory.
conclusionThe function of brain areas critical to memory performance varies with estrogen levels in the postmenopause, even though those levels are low. Higher levels of E2 may facilitate memory performance through enhanced function of temporal and frontal cortices during encoding of verbal material.
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