Evidence map›Paper›PMID 39026267›Full record

ArticleClinical epigenetics2024

Effects of walking on epigenetic age acceleration: a Mendelian randomization study.

Guan-Yi Chen, Chao Liu, Yu Xia, Ping-Xiao Wang, Zi-Yue Zhao, Ao-Yu Li, Chu-Qiao Zhou, Cheng Xiang, Jia-Lin Zhang, Yi Zeng and 2 more

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In one paragraph

Article in Clinical epigenetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
  4. Article
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Guan-Yi ChenDepartment of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, China.
Chao LiuDepartment of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, China.
Yu XiaDepartment of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, China.
Ping-Xiao WangDepartment of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, China.
Zi-Yue ZhaoDepartment of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, China.
Ao-Yu LiDepartment of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, China.
Chu-Qiao ZhouDepartment of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, China.
Cheng XiangDepartment of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, China.
Jia-Lin ZhangDepartment of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, China.
Yi ZengDepartment of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, China.
Peng GuDepartment of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, China.
Hui LiDepartment of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, China. lihuix@csu.edu.cn.

Funding

Fundamental Research Funds for Central Universities of the Central South University 2024ZZTS0937Research Project of Human Health Commission 202204073071
6 · The paper itself

Abstract

introductionWalking stands as the most prevalent physical activity in the daily lives of individuals and is closely associated with physical functioning and the aging process. Nonetheless, the precise cause-and-effect connection between walking and aging remains unexplored. The epigenetic clock emerges as the most promising biological indicator of aging, capable of mirroring the biological age of the human body and facilitating an investigation into the association between walking and aging. Our primary objective is to investigate the causal impact of walking with epigenetic age acceleration (EAA).

methodsWe conducted a two-sample two-way Mendelian randomization (MR) study to investigate the causal relationship between walking and EAA. Walking and Leisure sedentary behavior data were sourced from UK Biobank, while EAA data were gathered from a total of 28 cohorts. The MR analysis was carried out using several methods, including the inverse variance weighted (IVW), weighted median, MR-Egger, and robust adjusted profile score (RAPS). To ensure the robustness of our findings, we conducted sensitivity analyses, which involved the MR-Egger intercept test, Cochran's Q test, and MR-PRESSO, to account for and mitigate potential pleiotropy.

resultsThe IVW MR results indicate a significant impact of usual walking pace on GrimAge (BETA = - 1.84, 95% CI (- 2.94, - 0.75)), PhenoAge (BETA = - 1.57, 95% CI (- 3.05, - 0.08)), Horvath (BETA = - 1.09 (- 2.14, - 0.04)), and Hannum (BETA = - 1.63, 95% CI (- 2.70, - 0.56)). Usual walking pace is significantly associated with a delay in epigenetic aging acceleration (EAA) (P < 0.05). Moreover, the direction of effect predicted by the gene remained consistent across RAPS outcomes and sensitivity MR analyses. There is a lack of robust causal relationships between other walking conditions, such as walking duration and walking frequency, on EAA (P > 0.05).

conclusionOur evidence demonstrates that a higher usual walking pace is associated with a deceleration of the acceleration of all four classical epigenetic clocks acceleration.

Indexed as

AgingEpigenesis, GeneticMendelian Randomization AnalysisWalkingAgedDNA MethylationFemaleHumansMaleMiddle AgedSedentary BehaviorUnited KingdomAgingEpigenetic age accelerationEpigenetic clockGrimAgeHannumHorvathMendelian randomization studyPhenoAgeUsual walking paceWalking

Identifiers

PMID39026267
PMCPMC11256679

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.