Evidence map›Paper›PMID 39026081›Full record

ArticleBritish journal of cancer2024

Unraveling the role of hepatitis B virus DNA integration in B-cell lymphomagenesis.

Chieh-Lung Cheng, You-Yu Lin, Chia-Lang Hsu, Chiao-Ling Li, Chang-Tsu Yuan, Ya-Yun Lai, Wei-Quan Fang, Pei-Jer Chen, Shiou-Hwei Yeh, Hwei-Fang Tien

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Article in British journal of cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chieh-Lung ChengDivision of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC.ORCID http://orcid.org/0000-0001-5442-1079
You-Yu LinGenome and Systems Biology Degree Program, Academia Sinica and National Taiwan University, Taipei, Taiwan, ROC.
Chia-Lang HsuDepartment of Medical Research, National Taiwan University Hospital, Taipei, Taiwan, ROC.ORCID http://orcid.org/0000-0002-7447-8045
Chiao-Ling LiDepartment of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan, ROC.
Chang-Tsu YuanDepartment of Pathology, National Taiwan University Cancer Center, Taipei, Taiwan, ROC.
Ya-Yun LaiMicrobial Genomics Core Laboratory, Centers of Genomic and Precision Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Wei-Quan FangDivision of New Drug, Center for Drug Evaluation, Taipei, Taiwan, ROC.
Pei-Jer ChenMicrobial Genomics Core Laboratory, Centers of Genomic and Precision Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Shiou-Hwei YehDepartment of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan, ROC. shyeh@ntu.edu.tw.ORCID http://orcid.org/0000-0003-4509-180X
Hwei-Fang TienDivision of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC. hftien@ntu.edu.tw.ORCID http://orcid.org/0000-0002-1384-5593

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudies have shown that hepatitis B virus (HBV)-associated B-cell non-Hodgkin lymphoma (NHL) constitutes a unique subgroup with distinct clinical features. It still leaves open the question of whether the integration of HBV DNA into the B-cell genome is a causal mechanism in the development of lymphoma.

methodsUsing the hybridisation capture-based next generation sequencing and RNA sequencing, we characterised the HBV integration pattern in 45 HBV-associated B-cell NHL tumour tissues.

resultsA total of 354 HBV integration sites were identified in 13 (28.9%) samples, indicating the relatively low integration frequency in B-cell NHLs. High plasma HBV DNA loads were not associated with the existence of HBV integration. The insertion sites distributed randomly across all the lymphoma genome without any preferential hotspot neither at the chromosomal level nor at the genetic level. Intriguingly, most HBV integrations were nonclonal in B-cell NHLs, implying that they did not confer a survival advantage. Analysis of the paired diagnosis-relapse samples showed the unstable status of HBV integrations during disease progression. Furthermore, transcriptomic analysis revealed the limited biological impact of HBV integration.

conclusionOur study provides an unbiased HBV integration map in B-cell NHLs, revealing the insignificant role of HBV DNA integration in B-cell lymphomagenesis.

Indexed as

DNA, ViralHepatitis B virusLymphoma, B-CellVirus IntegrationAdultAgedFemaleHepatitis BHigh-Throughput Nucleotide SequencingHumansMaleMiddle AgedDNA, Viral

Identifiers

PMID39026081
PMCPMC11405389

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.