Evidence map›Paper›PMID 39025947›Full record

ArticleNPJ precision oncology2024

Metastatic renal cell carcinoma with occult primary: a multicenter prospective cohort.

Nicolas Jacquin, Ronan Flippot, Julien Masliah-Planchon, Guillaume Grisay, Riwan Brillet, Célia Dupain, Maud Kamal, Isabelle Guillou, Nadège Gruel, Nicolas Servant and 14 more

Abstract read
In one paragraph

Article in NPJ precision oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Case Report: Expansion of theFrontiers in oncology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Nicolas JacquinINSERM U830, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, Institut Curie Research Center, Paris, France.ORCID http://orcid.org/0009-0007-8309-7221
Ronan FlippotDepartment of Cancer Medicine, Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Julien Masliah-PlanchonSomatic Genetic Unit, Department of Genetics, Institut Curie Hospital, Paris, France.
Guillaume GrisayDepartment of Cancer Medicine, Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Riwan BrilletClinical Bioinformatic Unit, Department of Diagnostic and Theragnostic Medicine, Institut Curie Hospital, Paris, France.
Célia DupainDepartment of Drug Development and Innovation (D3i), Institut Curie, Paris, France.
Maud KamalDepartment of Drug Development and Innovation (D3i), Institut Curie, Paris, France.ORCID http://orcid.org/0000-0003-1466-0950
Isabelle GuillouDepartment of Drug Development and Innovation (D3i), Institut Curie, Paris, France.
Nadège GruelINSERM U830, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, Institut Curie Research Center, Paris, France.ORCID http://orcid.org/0000-0001-6915-8082
Nicolas ServantINSERM U900, CBIO-Centre for Computational Biology, Institut Curie Research Center, Mines ParisTech, Paris, France.ORCID http://orcid.org/0000-0003-1678-7410
Pierre GestraudINSERM U900, CBIO-Centre for Computational Biology, Institut Curie Research Center, Mines ParisTech, Paris, France.ORCID http://orcid.org/0000-0002-3893-9879
Jennifer WongSomatic Genetic Unit, Department of Genetics, Institut Curie Hospital, Paris, France.
Vincent CockenpotDepartment of Pathology, Institut Curie Hospital, Paris, France.ORCID http://orcid.org/0000-0002-7470-4436
Andreia GoncalvesDepartment of Pathology, Institut Curie Hospital, Paris, France.
Janick SelvesDepartment of Pathology, University Hospital of Toulouse (IUCT), Toulouse, France.
Hélène BlonsDepartment of Biochemistry, Pharmacogenetics and Molecular Oncology, Georges Pompidou European Hospital, APHP, Paris, France.ORCID http://orcid.org/0000-0002-0572-8426
Etienne RouleauPRISM Center for personalized medicine, Gustave Roussy Cancer Center, Villejuif, France.
Olivier DelattreINSERM U830, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, Institut Curie Research Center, Paris, France.
Claire GervaisDepartment of Medical Oncology, Georges Pompidou European Hospital, APHP, Paris, France.
Christophe Le TourneauDepartment of Drug Development and Innovation (D3i), Institut Curie, Paris, France.ORCID http://orcid.org/0000-0001-9772-4686
Ivan BiècheDepartment of Genetics, Institut Curie Hospital, INSERM U1016, Université Paris Cité, Paris, France.
Yves AlloryDepartment of Pathology, Institut Curie Hospital, Saint-Cloud, France. yves.allory@curie.fr.ORCID http://orcid.org/0000-0002-5526-077X
Laurence AlbigèsDepartment of Cancer Medicine, Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France. Laurence.albiges@gustaveroussy.fr.
Sarah WatsonINSERM U830, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, Institut Curie Research Center, Paris, France. sarah.watson@curie.fr.ORCID http://orcid.org/0000-0003-4534-8783

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metastatic carcinoma of presumed renal origin (rCUP) has recently emerged as a new entity within the heterogeneous entity of Cancers of Unknown Primary (CUP) but their biological features and optimal therapeutic management remain unknown. We report the molecular characteristics and clinical outcome of a series of 25 rCUP prospectively identified within the French National Multidisciplinary Tumor Board for CUP. This cohort strongly suggests that rCUP share similarities with common RCC subtypes and benefit from renal-tailored systemic treatment. This study highlights the importance of integrating clinical and molecular data for optimal diagnosis and management of CUP.

Identifiers

PMID39025947
PMCPMC11258290

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.