Evidence map›Paper›PMID 39025881›Full record

ArticleNature communications2024

Pyridine-based strategies towards nitrogen isotope exchange and multiple isotope incorporation.

Minghao Feng, Maylis Norlöff, Benoit Guichard, Steven Kealey, Timothée D'Anfray, Pierre Thuéry, Frédéric Taran, Antony Gee, Sophie Feuillastre, Davide Audisio

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Shape-Conserving Atom Replacements.Chemical reviews · 2026
    Review
  3. Review
  4. Article
  5. Synthesis of Thiophenes from Pyridines Using Elemental Sulfur.Angewandte Chemie (International ed. in English) · 2025
    Article
  6. EfficientJournal of magnetic resonance open · 2025
    Article
  7. Article
  8. Skeletal Editing Strategies Driven by Total Synthesis.Accounts of chemical research · 2025
    Article
  9. Article
  10. Heterocyclic Surgery for Isotopic Labeling.Synlett : accounts and rapid communications in synthetic organic chemistry · 2025
    Article
  11. Journal of the American Chemical Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Minghao FengUniversité Paris-Saclay, CEA, Service de Chimie Bio-organique et Marquage, DMTS, F-91191, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0002-8220-9187
Maylis NorlöffUniversité Paris-Saclay, CEA, Service de Chimie Bio-organique et Marquage, DMTS, F-91191, Gif-sur-Yvette, France.
Benoit GuichardUniversité Paris-Saclay, CEA, Service de Chimie Bio-organique et Marquage, DMTS, F-91191, Gif-sur-Yvette, France.
Steven KealeyKing's College London, School of Biomedical Engineering and Imaging Sciences, Department of Imaging Chemistry and Biology, 4th Floor Lambeth Wing, St Thomas' Hospital, London, SE1 7EH, UK.
Timothée D'AnfrayUniversité Paris-Saclay, CEA, Service de Chimie Bio-organique et Marquage, DMTS, F-91191, Gif-sur-Yvette, France.
Pierre ThuéryUniversité Paris-Saclay, CEA, CNRS, NIMBE, 91191, Gif-sur-Yvette, France.
Frédéric TaranUniversité Paris-Saclay, CEA, Service de Chimie Bio-organique et Marquage, DMTS, F-91191, Gif-sur-Yvette, France.
Antony GeeKing's College London, School of Biomedical Engineering and Imaging Sciences, Department of Imaging Chemistry and Biology, 4th Floor Lambeth Wing, St Thomas' Hospital, London, SE1 7EH, UK.ORCID http://orcid.org/0000-0001-8389-9012
Sophie FeuillastreUniversité Paris-Saclay, CEA, Service de Chimie Bio-organique et Marquage, DMTS, F-91191, Gif-sur-Yvette, France. sophie.feuillastre@cea.fr.ORCID http://orcid.org/0000-0002-9327-2050
Davide AudisioUniversité Paris-Saclay, CEA, Service de Chimie Bio-organique et Marquage, DMTS, F-91191, Gif-sur-Yvette, France. davide.audisio@cea.fr.ORCID http://orcid.org/0000-0002-6234-3610

Funding

EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 Marie Skłodowska-Curie Actions (H2020 Excellent Science - Marie Skłodowska-Curie Actions) 864576EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 862179RCUK | Engineering and Physical Sciences Research Council (EPSRC) EP/S032789/1
6 · The paper itself

Abstract

Isotopic labeling is at the core of health and life science applications such as nuclear imaging, metabolomics and plays a central role in drug development. The rapid access to isotopically labeled organic molecules is a sine qua non condition to support these societally vital areas of research. Based on a rationally driven approach, this study presents an innovative solution to access labeled pyridines by a nitrogen isotope exchange reaction based on a Zincke activation strategy. The technology conceptualizes an opportunity in the field of isotope labeling.

Identifiers

PMID39025881
PMCPMC11258231

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.