ArticleNature communications2024
Iron rescues glucose-mediated photosynthesis repression during lipid accumulation in the green alga Chromochloris zofingiensis.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Investigating overflow metabolism in heterotrophic cultures of the green alga Chromochloris zofingiensis.Metabolic engineering · 2026Article
- The sugar transporter STP1-driven trophic conversion of Chlamydomonas reinhardtii.Microbial cell factories · 2026Article
- Enhancement of growth and zeaxanthin accumulation via gene expression and metabolic pathways modulation in Chromochloris zofingiensis mutant CZ-Z12.Biotechnology for biofuels and bioproducts · 2026Article
- Investigating Overflow Metabolism in Heterotrophic Cultures of the Green AlgabioRxiv : the preprint server for biology · 2025Article
- An Algal Nutrient-Replete, Optimized Medium for Fast Growth and High Triacylglycerol Accumulation.Plant direct · 2025Article
- A distinct LHCI arrangement is recruited to photosystem I in Fe-starved green algae.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Carboxymethyl Cellulose Surface Modification Alleviates the Toxicity of Fe-MOFs to Rice and Improves Iron Absorption.Nanomaterials (Basel, Switzerland) · 2025Article
- Fe starvation induces a second LHCI tetramer to photosystem I in green algae.bioRxiv : the preprint server for biology · 2024Article
- Green microalgaFrontiers in microbiology · 2024Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Energy status and nutrients regulate photosynthetic protein expression. The unicellular green alga Chromochloris zofingiensis switches off photosynthesis in the presence of exogenous glucose (+Glc) in a process that depends on hexokinase (HXK1). Here, we show that this response requires that cells lack sufficient iron (-Fe). Cells grown in -Fe+Glc accumulate triacylglycerol (TAG) while losing photosynthesis and thylakoid membranes. However, cells with an iron supplement (+Fe+Glc) maintain photosynthesis and thylakoids while still accumulating TAG. Proteomic analysis shows that known photosynthetic proteins are most depleted in heterotrophy, alongside hundreds of uncharacterized, conserved proteins. Photosynthesis repression is associated with enzyme and transporter regulation that redirects iron resources to (a) respiratory instead of photosynthetic complexes and (b) a ferredoxin-dependent desaturase pathway supporting TAG accumulation rather than thylakoid lipid synthesis. Combining insights from diverse organisms from green algae to vascular plants, we show how iron and trophic constraints on metabolism aid gene discovery for photosynthesis and biofuel production.
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