Evidence map›Paper›PMID 39025525›Full record

ArticleLife science alliance2024

C/EBPβ deletion in macrophages impairs mammary gland alveolar budding during the estrous cycle.

Michelle D Rojo, Ishitri Bandyopadhyay, Caitlin M Burke, Alexa D Sturtz, Emily S Phillips, Megan G Matherne, Samuel J Embrey, Rebecca LaRue, Yinjie Qiu, Kathryn L Schwertfeger and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michelle D RojoDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA, USA.
Ishitri BandyopadhyayDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA, USA.
Caitlin M BurkeDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA, USA.
Alexa D SturtzDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA, USA.
Emily S PhillipsDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA, USA.
Megan G MatherneDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA, USA.ORCID 0009-0000-8871-8401
Samuel J EmbreyDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA, USA.
Rebecca LaRueDepartment of Laboratory Medicine and Pathology, Masonic Cancer Center, and Center for Immunology, University of Minnesota, Minneapolis, MN, USA.
Yinjie QiuDepartment of Laboratory Medicine and Pathology, Masonic Cancer Center, and Center for Immunology, University of Minnesota, Minneapolis, MN, USA.
Kathryn L SchwertfegerDepartment of Laboratory Medicine and Pathology, Masonic Cancer Center, and Center for Immunology, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-9755-7774
Heather L MachadoDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA, USA hmachado@tulane.edu.ORCID 0000-0001-6889-6139

Funding

"Project 3" MHV68 IncRNA/miRNA interaction in latency and lympomagenesisP01CA214091 · NCI · UNIVERSITY OF FLORIDA · PI ROLF F RENNE · 2017 to 2026
$15.9M
Contributions of FGFR-Mediated Tumor-Stromal Interactions to Breast Cancer Growth and ProgressionR01CA215052 · NCI · UNIVERSITY OF MINNESOTA · PI Kathryn L Schwertfeger · 2017 to 2026
$3.6M
Functions of ductal- and stromal-associated macrophages in the mammary glandR01HD106929 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI Heather L Machado, Kathryn L Schwertfeger · 2022 to 2026
$2.4M
Defining the contributions of Lyve-1 expressing macrophages to breast cancer growth and progressionR01CA265004 · NCI · UNIVERSITY OF MINNESOTA · PI Kathryn L Schwertfeger · 2022 to 2026
$2.0M
Regulation of tissue resident macrophages during mammary gland developmentR01HD095858 · NICHD · UNIVERSITY OF MINNESOTA · PI SCHWERTFEGER, KATHRYN L · 2018 to 2022
$1.9M
Mechanisms promoting the transition to invasive cancerR01CA212518 · NCI · TULANE UNIVERSITY OF LOUISIANA · PI MACHADO, HEATHER L · 2017 to 2021
$1.8M
Gas6 regulation of premalignant mammary cellsF31CA239445 · NCI · TULANE UNIVERSITY OF LOUISIANA · PI ROJO, MICHELLE D. · 2019 to 2021
$137k
NCI NIH HHS F31 CA239445NCI NIH HHS P01 CA214091NCI NIH HHS R01 CA212518NCI NIH HHS R01 CA215052NCI NIH HHS R01 CA265004NICHD NIH HHS R01 HD095858NICHD NIH HHS R01 HD106929
6 · The paper itself

Abstract

Macrophages have important roles in mammary gland development and tissue homeostasis, but the specific mechanisms that regulate macrophage function need further elucidation. We have identified C/EBPβ as an important transcription factor expressed by multiple macrophage populations in the normal mammary gland. Mammary glands from mice with C/EBPβ-deficient macrophages (

Indexed as

CCAAT-Enhancer-Binding Protein-betaEstrous CycleMacrophagesMammary Glands, AnimalAnimalsEpithelial CellsFemaleGene DeletionMiceMice, Inbred C57BLMice, KnockoutPhagocytosisReceptors, NotchCCAAT-Enhancer-Binding Protein-betaCebpb protein, mouseReceptors, Notch

Identifiers

PMID39025525
PMCPMC11258408

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.