Evidence map›Paper›PMID 39025205›Full record

ArticleChest2024

Unsupervised Exercise in Interstitial Lung Disease: A Delphi Study to Develop a Consensus Preparticipation Screening Tool for Lymphangioleiomyomatosis.

Claire E Child, Lawrence A Ho, Daniel Lachant, Nishant Gupta, Joel Moss, Amanda Jones, Rachana Krishna, Anne E Holland, MeiLan K Han, Cormac McCarthy and 6 more

Abstract readConsensus Statement
In one paragraph

Article in Chest, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Brazilian Thoracic Association recommendations for the management of lymphangioleiomyomatosis.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2025
    Guideline
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Claire E ChildDepartment of Rehabilitation Medicine, Division of Physical Therapy, University of Washington, Seattle, WA.
Lawrence A HoDepartment of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, WA.
Daniel LachantUniversity of Rochester, Rochester, NY.
Nishant GuptaUniversity of Cincinnati, Cincinnati, OH.
Joel MossCritical Care Medicine and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Amanda JonesCritical Care Medicine and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Rachana KrishnaMedical University of South Carolina, Charleston, SC.
Anne E HollandMonash University and Alfred Health, Melbourne, VIC, Australia; Institute for Breathing and Sleep, Melbourne, VIC, Australia.
MeiLan K HanUniversity of Michigan, Ann Arbor, MI.
Cormac McCarthySt. Vincent's University Hospital Dublin, Dublin, Ireland; University College Dublin, Dublin, Ireland.
Ali AtayaUniversity of Florida, Gainesville, FL.
Misbah BaqirMayo Clinic, Rochester, MN.
Daniel F DillingDivision of Pulmonary and Critical Care, Loyola University Chicago, Stritch School of Medicine, Maywood, IL.
Jeff SwigrisNational Jewish Health, Denver, CO.
Erik R SwensonVA Puget Sound Health Care System, Seattle, WA.
Mary Beth BrownDepartment of Rehabilitation Medicine, Division of Physical Therapy, University of Washington, Seattle, WA. Electronic address: mbbrown1@uw.edu.

Funding

Characterization of the Pathogenesis of Lymphangioleiomyomatosis (LAM)ZIAHL002541 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI MOSS, JOEL · 2009 to 2025
$47.7M
6 · The paper itself

Abstract

backgroundLittle research is available to provide practical guidance to health care providers for exercise preparticipation screening and referral of patients with interstitial lung diseases (ILDs), including lymphangioleiomyomatosis (LAM), to participate in remote, unsupervised exercise programs. RESEARCH QUESTION: What exercise preparticipation screening steps are essential to determine whether a patient with LAM is medically appropriate to participate in a remote, unsupervised exercise program? STUDY DESIGN AND

methodsSixteen experts in LAM and ILD participated in a two-round modified Delphi study, ranking their level of agreement for 10 statements related to unsupervised exercise training in LAM, with an a priori definition of consensus. Additionally, 60 patients with LAM completed a survey of the perceived risks and benefits of remote exercise training in LAM.

resultsSeven of the 10 statements reached consensus among experts. Experts agreed that an in-person clinical exercise test is indicated to screen for exercise-induced hypoxemia and prescribe supplemental oxygen therapy as indicated prior to initiating a remote exercise program. Patients with recent pneumothorax should wait to start an exercise program for at least 4 weeks until after resolution of pneumothorax and clearance by a physician. Patients with high cardiovascular risk for event during exercise, severe resting pulmonary hypertension, or risk for falls may be more appropriate for referral to a rehabilitation center. A LAM-specific remote exercise preparticipation screening tool was developed from the consensus statements and agreed upon by the panelists.

interpretationA modified Delphi study approach was useful to develop disease-specific recommendations for safety and preparticipation screening prior to unsupervised, remotely administered exercise in LAM. The primary product of this study is a clinical decision aid for providers to use when medically screening patients prior to participation in the newly launched LAMFit remote exercise program.

Indexed as

Delphi TechniqueLung Diseases, InterstitialLymphangioleiomyomatosisAdultExercise TestExercise TherapyFemaleHumansLung NeoplasmsMaleMass ScreeningMiddle AgedDelphi studydigital healthexercise risk stratificationexercise traininginterstitial lung diseaseLAMlymphangioleiomyomatosispreparticipation screeningremote monitoring

Identifiers

PMID39025205
PMCPMC11562656

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.