Evidence map›Paper›PMID 39025204›Full record

ArticleChest2024

Novel Reference Equations for Pulmonary Artery Size and Pulsatility Using Echocardiography and Their Diagnostic Value in Pulmonary Hypertension.

Shadi P Bagherzadeh, Bettia E Celestin, Everton J Santana, Michael Salerno, Kari C Nadeau, Andrew J Sweatt, Roham T Zamanian, Francois Haddad

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chest, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shadi P BagherzadehDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA; Stanford Cardiovascular Institute, Stanford University, Stanford, CA. Electronic address: shadip@stanford.edu.
Bettia E CelestinDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA; Sean N. Parker Center of Allergy and Asthma Research, Stanford, CA.
Everton J SantanaStanford Cardiovascular Institute, Stanford University, Stanford, CA.
Michael SalernoDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA; Stanford Cardiovascular Institute, Stanford University, Stanford, CA.
Kari C NadeauSean N. Parker Center of Allergy and Asthma Research, Stanford, CA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA.
Andrew J SweattDivision of Pulmonary and Critical Care Medicine, Stanford University, Stanford, CA; Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford, CA.
Roham T ZamanianDivision of Pulmonary and Critical Care Medicine, Stanford University, Stanford, CA; Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford, CA.
Francois HaddadDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA; Stanford Cardiovascular Institute, Stanford University, Stanford, CA.

Funding

Computational Medicine in the Heart, Integrated Training ProgramT32HL166155 · NHLBI · STANFORD UNIVERSITY · PI Alison L Marsden, Sanjiv M Narayan · 2023 to 2026
$2.0M
Reclassifying Pulmonary Arterial Hypertension Into Immune Phenotypes Using Machine LearningK23HL151892 · NHLBI · STANFORD UNIVERSITY · PI SWEATT, ANDREW JOHN · 2020 to 2024
$942k
NHLBI NIH HHS K23 HL151892NHLBI NIH HHS T32 HL166155
6 · The paper itself

Abstract

backgroundAccording to the most recent pulmonary hypertension (PH) guidelines, a main pulmonary artery (MPA) diameter > 25 mm on transthoracic echocardiography supports the diagnosis of PH. However, the size of the pulmonary artery (PA) may vary according to body size, age, and cardiac phases. RESEARCH QUESTION: (1) What are the reference limits for PA size on transthoracic echocardiography, considering differences in body size, sex, and age? (2) What is the diagnostic value of the PA size for classifying PH? (3) How does the selection of different reference groups (healthy volunteers vs patients referred for right heart catheterization [RHC]) influence the diagnostic OR (DOR)? STUDY DESIGN AND

methodsThe study included a reference cohort of 248 healthy individuals as control patients, 693 patients with PH proven by RHC, and 156 patients without PH proven by RHC. In the PH cohort, 300 had group 1 PH, 207 had group 2 PH, and 186 had group 3 PH. MPA and right PA diameters and areas were measured in the upper sternal short-axis and suprasternal notch views. Reference limits (5th-95th percentile) were based on absolute values and height-indexed measures. Quantile regression analysis was used to derive median and 95th quantile reference equations for the PA measures. DORs and probability diagnostic plots for PH were then determined using healthy control and non-PH cohorts.

resultsThe 95th percentile for indexed MPA diameter was 15 mm/m in diastole and 19 mm/m in systole in both sexes. Quantile regression analysis revealed a weak age effect (pseudo-R

interpretationThis study presents novel reference limits for MPA based on height indexing and quantile regression.

Indexed as

EchocardiographyHypertension, PulmonaryPulmonary ArteryAdultAgedCardiac CatheterizationFemaleHumansMaleMiddle AgedPulsatile FlowReference ValuesBayesian statisticsconditional modelingdetection of diseasediagnostic odds ratiodiagnostic studyechocardiographypulmonary hypertensionreference equations

Identifiers

PMID39025204
PMCPMC11638547

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.