ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2024
A set of diagnostic tests for detection of active Babesia duncani infection.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Characterization of vesicle-associated exported immunodominant antigens of the human pathogenInfection and immunity · 2026Article
- Human babesiosis: The past, present and future.Expert reviews in molecular medicine · 2025Review
- Research progress on diagnostic techniques for differentFrontiers in cellular and infection microbiology · 2025Review
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Abstract
objectivesHuman babesiosis is an emerging and potentially fatal tick-borne disease caused by intraerythrocytic parasites of the Babesia genus. Among these, Babesia duncani is particularly notable for causing severe and life-threatening illness in humans. Accurate diagnosis and effective disease management hinge on the detection of active B. duncani infections. While molecular assays are available to detect the parasite in blood, a reliable method for identifying biomarkers of active infection remains elusive.
methodsWe developed the first B. duncani antigen capture assays, targeting two immunodominant antigens, BdV234 and BdV38. These assays were validated using established in vitro and in vivo B. duncani infection models, and following drug treatment.
resultsThe assays demonstrated no cross-reactivity with other species such as B. microti, B. divergens, Babesia MO1, or Plasmodium falciparum, and can detect as few as 115 infected erythrocytes/µl of blood. Screening of 1731 blood samples from various biorepositories, including samples previously identified as Lyme and/or B. microti-positive, as well as new specimens from wild mice, revealed no evidence of B. duncani infection or cross-reactivity.
conclusionsThese assays hold significant promise for various applications, including point-of-care testing for the early detection of B. duncani in patients, field tests for screening reservoir hosts, and high-throughput screening of blood samples intended for transfusion.
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