Evidence map›Paper›PMID 39025051›Full record

ArticleCardiology2024

Elective Direct Current Cardioversion of Atrial Fibrillation: Silent Brain Infarction and Health-Related Quality of Life.

Peter M Andel, Anne Hege Aamodt, Jostein Gleditsch, Erik Melin, Mona Elisabeth Rootwelt-Revheim, Kjetil Steine, Dan Atar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Peter M AndelInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Anne Hege AamodtDepartment of Neurology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Jostein GleditschInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Erik MelinInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Mona Elisabeth Rootwelt-RevheimInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Kjetil SteineInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Dan AtarInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAtrial fibrillation (AF) increases the risk for stroke, dementia, and impaired health-related quality of life (HRQL). Elective direct current cardioversion (ECV) is often used to restore sinus rhythm but is associated with thromboembolism. While larger strokes usually produce symptoms, subclinical ones may go unrecognized and may cause cognitive and functional decline over time. In the current study, we sought to evaluate the effects of ECV on silent brain infarctions and HRQL in patients with AF.

methodsPatients with AF (n = 46) underwent brain magnetic resonance imaging (MRI) and HRQL assessment using the EuroQL-5D5L questionnaire before and after ECV. Implantable loop recorders (ILRs) were used to observe the rate of early AF recurrences within the first 30 days. All patients were treated with anticoagulants according to guidelines. The primary endpoint was silent brain infarction assessed by brain MRI within the first 2 weeks after ECV. Secondary endpoints were the change in HRQL and its association with AF recurrence at follow-up and by ILR recordings.

resultsNew silent brain infarction after ECV was detected in 1 patient. At follow-up visit after 19.1 days AF recurrence was detected by 12-lead ECG in 13 patients (28.3%), whereas 27 patients (58.7%) had AF recurrence recorded by ILR within the first 30 days after ECV. European Heart Rhythm Association (EHRA) symptom score and the EuroQL-5d5L score were improved after ECV.

conclusionSilent brain infarctions may occur after ECV despite anticoagulation treatment. Early AF recurrence is frequent. ECV positively affects HRQL mainly in those patients with sustained sinus rhythm at follow-up.

Indexed as

Atrial FibrillationBrain InfarctionElectric CountershockMagnetic Resonance ImagingQuality of LifeAgedAnticoagulantsFemaleHumansMaleMiddle AgedRecurrenceSurveys and QuestionnairesAnticoagulantsAtrial fibrillationCardioversionHealth-related quality of lifeSilent cerebral ischaemiaThromboembolic stroke

Identifiers

PMID39025051
PMCPMC11633895

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.