Evidence map›Paper›PMID 39024573›Full record

ArticleASN neuro2024

Cellular Mechanisms of Cognitive Enhancement: The

Lili Veronika Nagy, Zsolt Kristóf Bali, István Ledneczki, Zsolt Némethy, Balázs Lendvai, István Hernádi

Abstract read
In one paragraph

Article in ASN neuro, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lili Veronika NagyDepartment of Neurobiology, Faculty of Sciences, University of Pécs, Hungary.ORCID 0000-0001-7019-4363
Zsolt Kristóf BaliTranslational Neuroscience Research Group, Center for Neuroscience, Szentágothai Research Center, University of Pécs, Hungary.ORCID 0000-0003-0712-0788
István LedneczkiDepartment of Chemistry, Gedeon Richter Plc, Budapest, Hungary.
Zsolt NémethyPharmacology and Drug Safety Research, Gedeon Richter Plc, Budapest, Hungary.ORCID 0000-0002-0909-4416
Balázs LendvaiPharmacology and Drug Safety Research, Gedeon Richter Plc, Budapest, Hungary.ORCID 0000-0001-9289-4715
István HernádiDepartment of Neurobiology, Faculty of Sciences, University of Pécs, Hungary.ORCID 0000-0001-7882-4817

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Promising new pharmacological strategies for the enhancement of cognition target either nicotinic acetylcholine receptors (nAChR) or N-methyl-D-aspartate receptors (NMDAR). There is also an increasing interest in low-dose combination therapies co-targeting the above neurotransmitter systems to reach greater efficacy over the monotreatments and to reduce possible side effects of high-dose monotreatments. In the present study, we assessed modulatory effects of the α7 nAChR-selective agonist PHA-543613 (PHA), a novel α7 nAChR positive allosteric modulator compound (CompoundX) and the NMDAR antagonist memantine on the

Indexed as

alpha7 Nicotinic Acetylcholine ReceptorHippocampusMemantineAction PotentialsAnimalsCognitionDose-Response Relationship, DrugExcitatory Amino Acid AntagonistsLigandsMaleNeuronsNicotinic AgonistsNootropic AgentsRatsRats, Wistaralpha7 Nicotinic Acetylcholine ReceptorExcitatory Amino Acid AntagonistsLigandsMemantineNicotinic AgonistsNootropic AgentsAcetylcholinecombined treatmentelectrophysiologyhippocampusN-methyl-D-aspartateα7 nicotinic acetylcholine receptor

Identifiers

PMID39024573
PMCPMC11262468

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.