ArticleScience (New York, N.Y.)2024
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
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In one paragraph
Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 338 papers, 21 of them syntheses that pooled it.
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338citing papers in PubMed, 21 pooled it
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Who cites it
338 citing papers in PubMed, 21 syntheses or guidelines pooled it.
- Integration of GWAS and single-cell analysis for psoriasis identifies disease-associated cell subtypes and therapeutic targets.Nature communications · 2026Pooled it
- Genome-wide meta-analysis with 1,590,596 individuals identifies 12 novel risk loci for systemic lupus erythematosus.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Pooled it
- Multi-population GWAS meta-analysis identifies bladder cancer susceptibility loci and highlights genetic regulation of smoking-related risk.Nature communications · 2026Pooled it
- Genome-wide meta-analysis of quantitatively measured generalized anxiety symptoms in individuals of European ancestry.Nature human behaviour · 2026Pooled it
- Multi-ancestry genome-wide association analyses provide insights into the genetic basis of Hashimoto's thyroiditis.Nature genetics · 2026Pooled it
- Genetic drivers of etiologic heterogeneity in thyroid cancer.Nature communications · 2026Pooled it
- Genome-wide analysis implicates inner ear development in Ménière disease.American journal of human genetics · 2026Pooled it
- Pooled it
- Development and validation of a multiancestry and multitrait polygenic risk score for lung cancer.Nature communications · 2026Pooled it
- Circulating Inflammatory Proteins and Fuchs Endothelial Corneal Dystrophy: A Mendelian Randomization and Bioinformatics-Based Investigation.Translational vision science & technology · 2026Pooled it
- Multi-ancestry genome-wide association study of serum creatine kinase implicates myopathy genes and muscle pathways.EBioMedicine · 2026Pooled it
- Genetic architecture of lumbar spinal stenosis.Nature communications · 2026Pooled it
- The genetic basis of dermatophytosis skin infection susceptibility.Nature communications · 2026Pooled it
- Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk.Nature genetics · 2026Pooled it
- Genome-wide meta-analysis identifies genetic risk loci for mono- and polyneuropathies in 983 477 individuals.Human molecular genetics · 2026Pooled it
- Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.Nature genetics · 2026Pooled it
- The genetics of cannabis lifetime use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Pooled it
- Integrated multi-omics mapping of the causal landscape of gout across the circulating-tissue axis.Frontiers in immunology · 2026Pooled it
- Identification of new overlapping and disease-specific genetic risk factors for rheumatoid arthritis and radiographic axial spondyloarthritis: a meta-analysis of three large European populations and functional characterization.Frontiers in immunology · 2026Pooled it
- Multi-layered functional genomics prioritizes candidate effectors and regulatory mechanisms of ankylosing spondylitis.Frontiers in immunology · 2026Pooled it
278 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
71 authors.
Anurag Verma *Corporal Michael Crescenz VA Medical Center, Philadelphia, PA 19104, USA.ORCID 0000-0002-5063-9107
Jennifer E Huffman *Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA 02130, USA.ORCID 0000-0002-9672-2491
Alex Rodriguez *Data Science and Learning, Argonne National Laboratory, Lemont, IL 60439, USA.ORCID 0000-0003-0723-665X
Mitchell Conery *Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA 19104, USA.ORCID 0000-0001-7640-0797
Molei Liu *Department of Biostatistics, Columbia University's Mailman School of Public Health, New York, NY 10032, USA.ORCID 0000-0003-1890-4449
Yuk-Lam HoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA 02130, USA.ORCID 0000-0003-3305-3830
Youngdae KimMathematics and Computer Science Division, Argonne National Laboratory, Lemont, IL 60439, USA.ORCID 0000-0002-0120-7965
David A HeiseNational Security Sciences Directorate, Cyber Resilience and Intelligence Division, Oak Ridge National Laboratory, Dept of Energy, Oak Ridge, TN 37831, USA.ORCID 0000-0003-4524-5530
Lindsay GuareDepartment of Medicine, Division of Translational Medicine and Human Genetics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA 19104, USA.ORCID 0000-0001-6988-5319
Vidul Ayakulangara PanickanDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-0616-0403
Helene GarconMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA 02130, USA.
Franciel LinaresR&D Systems Engineering, Information Technology Services Directorate, Oak Ridge National Laboratory, Dept of Energy, Oak Ridge, TN 37831, USA.ORCID 0000-0002-3328-7736
Lauren CostaMVP Boston Coordinating Center, VA Boston Healthcare System, Boston, MA 02111, USA.ORCID 0000-0001-7237-5336
Ian GoethertData Management and Engineering, Information Technology Services Division, Oak Ridge National Laboratory, Dept of Energy, Oak Ridge, TN 37831, USA.ORCID 0000-0002-6978-1939
Ryan TiptonKnowledge Discovery Infrastructure, Information Technology Services Division, Oak Ridge National Laboratory, Dept of Energy, Oak Ridge, TN 37831, USA.
Jacqueline HonerlawMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA 02130, USA.ORCID 0000-0002-5872-359X
Laura DaviesComputing and Computational Sciences Dir PMO, PMO, Oak Ridge National Laboratory, Dept of Energy, Oak Ridge, TN 37831, USA.
Stacey WhitbourneDepartment of Medicine, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-3472-3464
Jeremy CohenNational Security Sciences Directorate, Cyber Resilience and Intelligence Division, Oak Ridge National Laboratory, Dept of Energy, Oak Ridge, TN 37831, USA.ORCID 0009-0004-1720-551X
Daniel C PosnerMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA 02130, USA.ORCID 0000-0002-3056-6924
Rahul SangarMVP Boston Coordinating Center, VA Boston Healthcare System, Boston, MA 02111, USA.
Michael MurrayMVP Boston Coordinating Center, VA Boston Healthcare System, Boston, MA 02111, USA.
Xuan WangDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
Daniel R DochtermannVA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA 02130, USA.ORCID 0000-0001-9513-5124
Poornima DevineniVA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA 02130, USA.
Yunling ShiVA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA 02130, USA.
Tarak Nath NandiData Science and Learning, Argonne National Laboratory, Lemont, IL 60439, USA.ORCID 0000-0002-7050-6619
Themistocles L AssimesMedicine, Cardiology, VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA.ORCID 0000-0003-2349-0009
Charles A BrunetteDepartment of Medicine, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-1620-3526
Robert J CarrollDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37211, USA.ORCID 0000-0003-3802-8183
Royce CliffordResearch Department, VA San Diego Healthcare System, San Diego, CA 92161, USA.ORCID 0000-0002-5515-4336
Scott DuvallVA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT 84148, USA.ORCID 0000-0002-4898-3865
Joel GelernterPsychiatry, Human Genetics, Yale University, New Haven, CT, 06520, USA.ORCID 0000-0002-4067-1859
Adriana HungMedicine, Nephrology & Hypertension, VA Tennessee Valley Healthcare System & Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0002-3203-1608
Sudha K IyengarDepartments of Population and Quantitative Health Sciences, Genetics and Genome Sciences, and Ophthalmology and Visual Sciences and the Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0001-7488-250X
Jacob JosephMedicine, Cardiology Section, VA Providence Healthcare System, Providence, RI 02908, USA.ORCID 0000-0002-7279-4896
Rachel KemberMental Illness Research, Education and Clinical Center, Corporal Michael Crescenz VA Medical Center, Philadelphia, PA 19104, USA.ORCID 0000-0001-8820-2659
Henry KranzlerMental Illness Research, Education and Clinical Center, Corporal Michael Crescenz VA Medical Center, Philadelphia, PA 19104, USA.ORCID 0000-0002-1018-0450
Colleen M KripkeDepartment of Medicine, Division of Translational Medicine and Human Genetics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA 19104, USA.ORCID 0009-0007-3117-685X
Daniel LeveyPsychiatry, Human Genetics, Yale University, New Haven, CT, 06520, USA.ORCID 0000-0001-8431-9569
Shiuh-Wen LuohVA Portland Health Care System, Portland, OR 97239, USA.
Victoria C MerrittResearch Department, VA San Diego Healthcare System, San Diego, CA 92161, USA.ORCID 0000-0001-5683-4168
Cassie OverstreetPsychiatry, Human Genetics, Yale University, New Haven, CT, 06520, USA.
Joseph D DeakPsychiatry, Yale University, New Haven, CT 06520, USA.ORCID 0000-0002-0540-6080
Struan F A GrantCenter for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0003-2025-5302
Renato PolimantiPsychiatry, Yale University, New Haven, CT 06520, USA.ORCID 0000-0003-0745-6046
Panos RoussosPsychiatry, Mental Illness Research, Education and Clinical Center, James J. Peters VA Medical Center; Icahn School of Medicine at Mount Sinai, Bronx, NY 10468, USA.ORCID 0000-0002-4640-6239
Gabrielle ShaktCorporal Michael Crescenz VA Medical Center, Philadelphia, PA 19104, USA.ORCID 0009-0001-9599-6351
Yan V SunEpidemiology, Emory University Rollins School of Public Health, Atlanta, GA 30322, USA.ORCID 0000-0002-2838-1824
Noah TsaoCorporal Michael Crescenz VA Medical Center, Philadelphia, PA 19104, USA.ORCID 0000-0002-5743-0795
Sanan VenkateshPsychiatry, Mental Illness Research, Education and Clinical Center, James J. Peters VA Medical Center; Icahn School of Medicine at Mount Sinai, Bronx, NY 10468, USA.ORCID 0000-0002-3094-2731
Georgios VoloudakisPsychiatry, Mental Illness Research, Education and Clinical Center, James J. Peters VA Medical Center; Icahn School of Medicine at Mount Sinai, Bronx, NY 10468, USA.ORCID 0000-0002-5729-632X
Amy JusticeMedicine, VA Connecticut Healthcare System West Haven, West Haven, CT 06516, USA.
Edmon BegoliOak Ridge National Laboratory, Dept of Energy, Oak Ridge, TN, 37831, USA.ORCID 0000-0002-2173-3663
Rachel RamoniOffice of Research and Development, Department of Veterans Affairs, Washington, DC, 20420, USA.ORCID 0000-0002-1459-9638
Georgia TourassiNational Center for Computational Sciences, Oak Ridge National Laboratory, Dept of Energy, Oak Ridge, TN, 37831, USA.
Saiju PyarajanVA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA 02130, USA.
Philip TsaoMedicine, Cardiology, VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA.ORCID 0000-0001-7274-9318
Christopher J O'DonnellMedicine, Cardiology, VA Boston Healthcare System, Boston, MA 02130, USA.ORCID 0000-0002-2667-8624
Sumitra MuralidharOffice of Research and Development, Department of Veterans Affairs, Washington, DC, 20420, USA.
Jennifer MoserOffice of Research and Development, Department of Veterans Affairs, Washington, DC, 20420, USA.ORCID 0009-0007-4972-8704
Juan P CasasMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA 02130, USA.
Alexander G BickDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University, Nashville, TN, 37325, USA.ORCID 0000-0001-5824-9595
Wei ZhouDepartment of Medicine, Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0001-7719-0859
Tianxi Cai *Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-5379-2502
Benjamin F Voight *Corporal Michael Crescenz VA Medical Center, Philadelphia, PA 19104, USA.ORCID 0000-0002-6205-9994
Kelly Cho *Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
J Michael Gaziano *Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-5384-9767
Ravi K Madduri *Data Science and Learning, Argonne National Laboratory, Lemont, IL 60439, USA.ORCID 0000-0003-2130-2887
Scott Damrauer *Corporal Michael Crescenz VA Medical Center, Philadelphia, PA 19104, USA.ORCID 0000-0001-8009-1632
Katherine P Liao *Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA 02130, USA.ORCID 0000-0002-4797-3200
Funding
Clinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5MTISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7MUnderstanding the molecular mechanisms that contribute to neuropsychiatric symptoms in Alzheimer DiseaseR01AG067025 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FINKBEINER, STEVEN M, HAROUTUNIAN, VAHRAM · 2019 to 2023
$11.8MUnderstanding the protective and neuroinflammatory role of human brain immune cells in Alzheimer DiseaseR01AG065582 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HAROUTUNIAN, VAHRAM, ROUSSOS, PANAGIOTIS · 2020 to 2024
$9.9MVERITY: Value and Evidence in Rheumatology using bioInformaTics, and advanced analYticsP30AR072577 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Daniel Hal Solomon · 2017 to 2026
$9.8MFunctional Interrogation of T2D-associated genes in human stem cell-derived models and miceUM1DK126194 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI GRANT, STRUAN F A, KAESTNER, KLAUS H · 2020 to 2024
$8.8MRESOURCE/SERVICE CORE C - MOLECULAR INFORMATICS MODULEP30EY025585 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI BELA ANAND-APTE · 2016 to 2026
$7.7MFrom GWAS to PheWAS: Scanning the EMR Phenome for Gene-disease AssociationsR01LM010685 · NLM · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BASTARACHE, LISA · 2011 to 2022
$6.3MUnravelling genetic basis of comorbidity using EHR-linked biobank dataR01GM138597 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI KIM, DOKYOON · 2020 to 2023
$2.2MTranslational Alcohol Research Program (TARP)T32AA028259 · NIAAA · YALE UNIVERSITY · PI COSGROVE, KELLY P., VASILIOU, VASILIS · 2020 to 2024
$1.8MCharacterizing and targeting subphenotypes of schizophrenia and bipolar disorder via individually imputed tissue and cell-type specific transcriptomesK08MH122911 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI VOLOUDAKIS, GEORGIOS · 2020 to 2023
$770kAn integrative approach to disease gene discovery combining genetic variation, gene expression, and epigenetics.K99HG012222 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI ZHOU, WEI · 2022 to 2023
$319kBLRD VA I01 BX003364BLRD VA I01 BX004189BLRD VA I01 BX004821BLRD VA I01 BX005831CSRD VA I01 CX001737CSRD VA I01 CX001849CSRD VA IK2 CX001780NCATS NIH HHS UL1 TR002548NEI NIH HHS P30 EY011373NEI NIH HHS P30 EY025585NHGRI NIH HHS K99 HG012222NIAAA NIH HHS T32 AA028259NIAMS NIH HHS P30 AR072577NIA NIH HHS R01 AG065582NIA NIH HHS R01 AG067025NIDDK NIH HHS UM1 DK126194NIGMS NIH HHS R01 GM138597NIMH NIH HHS K08 MH122911NLM NIH HHS R01 LM010685
Abstract
One of the justifiable criticisms of human genetic studies is the underrepresentation of participants from diverse populations. Lack of inclusion must be addressed at-scale to identify causal disease factors and understand the genetic causes of health disparities. We present genome-wide associations for 2068 traits from 635,969 participants in the Department of Veterans Affairs Million Veteran Program, a longitudinal study of diverse United States Veterans. Systematic analysis revealed 13,672 genomic risk loci; 1608 were only significant after including non-European populations. Fine-mapping identified causal variants at 6318 signals across 613 traits. One-third (
Indexed as
Genetic Predisposition to DiseaseGenome-Wide Association StudyQuantitative Trait LociVeteransFemaleGenetic VariationHumansLongitudinal StudiesMalePolymorphism, Single NucleotideUnited StatesUnited States Department of Veterans Affairs
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