ArticleCell reports2024
Mixing novel and familiar cues modifies representations of familiar visual images and affects behavior.
Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Dentate gyrus interneurons modulate winner-take-all network dynamics in freely behaving mice.Neuron · 2026Article
- Disruption of psychostimulant-associated memories by single, low dose ketamine in rats.Neuropharmacology · 2026Article
- State-space kinetic Ising model reveals task-dependent entropy flow in sparsely active nonequilibrium neuronal dynamics.Nature communications · 2025Article
- Map of spiking activity underlying change detection in the mouse visual system.bioRxiv : the preprint server for biology · 2025Article
- Diversity of omission responses to visual images across brain-wide regions.Science advances · 2025Article
- Electroanatomy of hippocampal activity patterns: theta, gamma waves, sharp wave-ripples, and dentate spikes.Frontiers in behavioral neuroscience · 2025Article
- Perpetual step-like restructuring of hippocampal circuit dynamics.Cell reports · 2024Article
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Authors and funding
5 authors.
Funding
Abstract
While visual responses to familiar and novel stimuli have been extensively studied, it is unknown how neuronal representations of familiar stimuli are affected when they are interleaved with novel images. We examined a large-scale dataset from mice performing a visual go/no-go change detection task. After training with eight images, six novel images were interleaved with two familiar ones. Unexpectedly, we found that the behavioral performance in response to familiar images was impaired when they were mixed with novel images. When familiar images were interleaved with novel ones, the dimensionality of their representation increased, indicating a perturbation of their neuronal responses. Furthermore, responses to familiar images in the primary visual cortex were less predictive of responses in higher-order areas, indicating less efficient communication. Spontaneous correlations between neurons were predictive of responses to novel images, but less so to familiar ones. Our study demonstrates the modification of representations of familiar images by novelty.
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Registered trials
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