Evidence map›Paper›PMID 39023805›Full record

ArticleNeurochemical research2024

Epidermal Neural Crest Stem Cell Conditioned Medium Enhances Spinal Cord Injury Recovery via PI3K/AKT-Mediated Neuronal Apoptosis Suppression.

Ziqian Ma, Tao Liu, Liang Liu, Yilun Pei, Tianyi Wang, Zhijie Wang, Yun Guan, Xinwei Zhang, Yan Zhang, Xueming Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurochemical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ziqian Ma *Department of Orthopedics Surgery, Beijing Luhe Hospital, Capital Medical University, Beijing, China.ORCID http://orcid.org/0000-0003-1245-378X
Tao Liu *Department of Orthopedics Surgery, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
Liang LiuDepartment of Orthopedics Surgery, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
Yilun PeiDepartment of Orthopedics Surgery, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
Tianyi WangDepartment of Orthopedics, 981st Hospital of the Chinese People's Liberation Army Joint Logistics Support Force, Chengde, 067000, Hebei Province, P.R. China.
Zhijie WangDepartment of Pediatric Internal Medicine, Affiliated Hospital of Chengde Medical University, Chengde, China.
Yun GuanDepartment of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Xinwei ZhangDepartment of Orthopedics Surgery, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
Yan ZhangDepartment of Orthopedics Surgery, Beijing Luhe Hospital, Capital Medical University, Beijing, China. zhangyanorth@mail.ccmu.edu.cn.
Xueming ChenDepartment of Orthopedics Surgery, Beijing Luhe Hospital, Capital Medical University, Beijing, China. chenxueming@ccmu.edu.cn.ORCID http://orcid.org/0009-0001-8681-9660

Funding

Beijing Tongzhou District high-level Talents Development Support Program YHDJ2019007the General Program of Natural Science Foundation of Hebei Province of China H2020406027Youth Incubation Foundation of Capital Medical University Beijing Luhe Hospital LHYY2023-JC104
6 · The paper itself

Abstract

This study aimed to assess the impact of conditioned medium from epidermal neural crest stem cells (EPI-NCSCs-CM) on functional recovery following spinal cord injury (SCI), while also exploring the involvement of the PI3K-AKT signaling pathway in regulating neuronal apoptosis. EPI-NCSCs were isolated from 10-day-old Sprague-Dawley rats and cultured for 48 h to obtain EPI-NCSC-CM. SHSY-5Y cells were subjected with H

Indexed as

ApoptosisNeural Stem CellsNeuronsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRats, Sprague-DawleySpinal Cord InjuriesAnimalsCulture Media, ConditionedMaleNeural CrestRatsRecovery of FunctionSignal TransductionCulture Media, ConditionedPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktCondition mediumEpidermal neural crest stem cellsNeuronal apoptosisPI3K/AKT signaling pathwaySHSY-5Y cell lineSpinal cord injury

Identifiers

PMID39023805
PMCPMC11365850

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.