Evidence map›Paper›PMID 39023666›Full record

ArticleBioresources and bioprocessing2024

Co-immobilization of amine dehydrogenase and glucose dehydrogenase for the biosynthesis of (S)-2-aminobutan-1-ol in continuous flow.

Pengcheng Xie, Jin Lan, Jingshuan Zhou, Zhun Hu, Jiandong Cui, Ge Qu, Bo Yuan, Zhoutong Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioresources and bioprocessing, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pengcheng XieCollege of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China.
Jin LanCollege of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China.
Jingshuan ZhouCollege of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China.
Zhun HuInstitute of Industrial Catalysis, School of Chemical Engineering and Technology, Xi'an Jiaotong University, Xi'an Shaanxi, 710049, China.
Jiandong CuiCollege of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China.
Ge QuTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Bo YuanTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China. yuanb@tib.cas.cn.
Zhoutong SunTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China. sunzht@tib.cas.cn.ORCID http://orcid.org/0000-0002-9923-0951

Funding

National Key Research and Development Program of China 2019YFA0905100National Key Research and Development Program of China 2021YFA0910400National Natural Science Foundation of China 32171462Natural Science Foundation of Tianjin 21JCJQJC00110Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project TSBICIP-CXRC-040
6 · The paper itself

Abstract

Reductive amination by amine dehydrogenases is a green and sustainable process that produces only water as the by-product. In this study, a continuous flow process was designed utilizing a packed bed reactor filled with co-immobilized amine dehydrogenase wh84 and glucose dehydrogenase for the highly efficient biocatalytic synthesis of chiral amino alcohols. The immobilized amine dehydrogenase wh84 exhibited better thermo-, pH and solvent stability with high activity recovery. (S)-2-aminobutan-1-ol was produced in up to 99% conversion and 99% ee in the continuous flow processes, and the space-time yields were up to 124.5 g L

Indexed as

Amine dehydrogenasesAsymmetric reductive aminationCo-immobilizationContinuous flowPacked bed reactor

Identifiers

PMID39023666
PMCPMC11258105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.