Evidence map›Paper›PMID 39023557›Full record

ArticleVirchows Archiv : an international journal of pathology2025

Conundrum of 3N: nasopharyngeal nonkeratinizing non-viral carcinoma-reappraisal of fusions and report of two consecutive cases with unusual molecular findings.

Diana Bell, Michelle Afkhami

Erratum issuedAbstract readCase Reports
PubMed Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Diana BellHead and Neck/Endocrine Pathology Center of Excellence, Division of Anatomic Pathology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA, 15261, USA. belldiana@yahoo.com.
Michelle AfkhamiDepartment of Molecular Diagnostics and Biomarkers, City of Hope Cancer Center, Duarte, CA, 91010, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nasopharyngeal carcinoma (NPC) has a unique and complex etiology that is not completely understood. NPC genome has been scrutinized by molecular studies, but small biopsy material and heavy infiltration of nonmalignant cells present major technical challenges. Over the past decade, significant progress in sinonasal tumor taxonomy has taken place with the discovery of tumor-specific fusion oncogenes generated by chromosomal translocation information. We report two consecutive nonviral-associated nonkeratinizing NPCs and their integrated morphological, phenotypical, and molecular characterization, with emphasis on fusions. Both NPCs harbored individual fusions, YAP1::MAML2 and FGFR3::TACC3,respectively.

Indexed as

Biomarkers, TumorNasopharyngeal CarcinomaNasopharyngeal NeoplasmsOncogene Proteins, FusionAdaptor Proteins, Signal TransducingCarcinomaDNA-Binding ProteinsGene FusionHumansMicrotubule-Associated ProteinsNuclear ProteinsPhosphoproteinsReceptor, Fibroblast Growth Factor, Type 3Trans-ActivatorsTranscription FactorsYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingBiomarkers, TumorDNA-Binding ProteinsFGFR3 protein, humanMAML2 protein, humanMicrotubule-Associated ProteinsNuclear ProteinsOncogene Proteins, FusionPhosphoproteinsReceptor, Fibroblast Growth Factor, Type 3TACC3 protein, humanTrans-ActivatorsTranscription FactorsYAP1 protein, humanYAP-Signaling ProteinsFGFR3::TACC3Fusion genesNasopharyngeal carcinomaNonkeratinizingYAP1::MAML2

Identifiers

PMID39023557

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.