Evidence map›Paper›PMID 39023541›Full record

ArticleClinical neuroradiology2024

Comparative Efficacy of Flow Diverter Devices in the Treatment of Carotid Sidewall Intracranial Aneurysms: a Retrospective, Multicenter Study.

Adam A Dmytriw, Hamza Adel Salim, Basel Musmar, Nicole M Cancelliere, Christoph J Griessenauer, Robert W Regenhardt, Jesse Jones, Vincent Tutino, Zuha Hasan, Nicola Limbucci and 46 more

Abstract readMulticenter StudyComparative Study
PubMed Publisher
In one paragraph

Article in Clinical neuroradiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Comparative safety, efficacy, and predictors of complete occlusion of flow diverter devices in the treatment of unruptured distal anterior cerebral artery aneurysms.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

56 authors.

Adam A DmytriwNeurovascular Centre, Departments of Medical Imaging and Neurosurgery, St. Michael's Hospital, Toronto, ON, Canada. admytriw@mgh.harvard.edu.
Hamza Adel SalimNeuroendovascular Program, Massachusetts General Hospital, Harvard University, Boston, MA, USA. Hamza.sleeem@gmail.com.ORCID http://orcid.org/0000-0002-5208-8425
Basel MusmarDepartment of Neurosurgery and Interventional Neuroradiology, Louisiana State University, Baton Rouge, LA, USA.
Nicole M CancelliereDepartment of Neuroradiology, St. Michael's Hospital, Toronto, ON, Canada.
Christoph J GriessenauerDepartment of Neurosurgery, Christian Doppler University Hospital & Institute of Neurointervention, Salzburg, Austria.
Robert W RegenhardtDepartment of Neuroradiology, Massachusetts General Hospital & Brigham and Women's Hospital, Boston, MA, USA.
Jesse JonesDeparments of Neurosurgery and Radiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Vincent TutinoDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Zuha HasanNeurovascular Centre, Departments of Medical Imaging and Neurosurgery, St. Michael's Hospital, Toronto, ON, Canada.
Nicola LimbucciDepartment of Neurosurgery and Neuroradiology, New York Presbyterian Hospital and Weill Cornell School of Medicine, New York, NY, USA.
Sovann V LayDepartment of Neuroradiology, Centre Hospitalier de Toulouse, Toulouse, France.
Julian SpearsNeurovascular Centre, Departments of Medical Imaging and Neurosurgery, St. Michael's Hospital, Toronto, ON, Canada.
James D RabinovDepartment of Neuroradiology, Massachusetts General Hospital & Brigham and Women's Hospital, Boston, MA, USA.
Mark R HarriganNeurovascular Centre, Departments of Medical Imaging and Neurosurgery, St. Michael's Hospital, Toronto, ON, Canada.
Adnan H SiddiquiDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Elad I LevyDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Christopher J StapletonDepartment of Neuroradiology, Massachusetts General Hospital & Brigham and Women's Hospital, Boston, MA, USA.
Leonardo RenieriInterventistica Neurovascolare, Ospedale Careggi di Firenze, Florence, Italy.
Christophe CognardDepartment of Diagnostic and Therapeutic Neuroradiology, Toulouse University Hospital, Toulouse, France.
Hamza ShaikhDepartment of Neuroradiology, Clinical Hospital Center 'Sisters of Mercy', Zagreb, Croatia.
Anna Luisa KühnDivision of Neurointerventional Radiology, Department of Radiology, University of Massachusetts Medical Center, Worcester, MA, USA.
Markus A MöhlenbruchSektion Vaskuläre und Interventionelle Neuroradiologie, Universitätsklinikum Heidelberg, Heidelberg, Germany.
Stavropoula I TjoumakarisDepartment of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Pascal JabbourDepartment of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA.
Philipp TausskyDepartment of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, UT, USA.
Fabio SettecaseDivision of Neuroradiology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Manraj K S HeranDivision of Neuroradiology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Anh NguyenDepartment of Neuroradiology, University Hospital of Basel, Basel, Switzerland.
David VoldersDivisions of Neuroradiology & Neurosurgery, QEII Health Sciences Centre, Dalhousie Medical School, Halifax, NS, USA.
Pablo HarkerDepartment of Neurology, University of Cincinnati Medical Center, Cincinnati, OH, USA.
Diego A DeviaHospital Universitario San Ignacio, Pontificia Universidad Javeriana School of Medicine Bogotá, Bogotá, Colombia.
Ajit S PuriDepartment of Neuroradiology, UMass Memorial Hospital, Worcester, MA, USA.
Marios PsychogiosDepartment of Neuroradiology, University Hospital of Basel, Basel, Switzerland.
Juan C PuentesHospital Universitario San Ignacio, Pontificia Universidad Javeriana School of Medicine Bogotá, Bogotá, Colombia.
Giuseppe LeoneUnit of Interventional Neuroradiology, Department of Advanced Diagnostic and Therapeutic Technologies, A.O.R.N. Antonio Cardarelli Hospital, Via Cardarelli 1, Naples, Italy.
Giuseppe BuonoUnit of Interventional Neuroradiology, Department of Advanced Biomedical Sciences, "Federico II" University, Naples, Italy.
Margherita TarantinoUnit of Interventional Neuroradiology, Department of Advanced Biomedical Sciences, "Federico II" University, Naples, Italy.
Mario MutoUnit of Interventional Neuroradiology, Department of Advanced Diagnostic and Therapeutic Technologies, A.O.R.N. Antonio Cardarelli Hospital, Via Cardarelli 1, Naples, Italy.
Francesco BrigantiUnit of Interventional Neuroradiology, Department of Advanced Diagnostic and Therapeutic Technologies, A.O.R.N. Antonio Cardarelli Hospital, Via Cardarelli 1, Naples, Italy.
Shamsher DalalDepartments of Neurosurgery and Radiology, Geisinger Hospital, Danville, PA, USA.
Vamsi GontuDepartments of Neuroradiology and Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.
Rodolfo E Alcedo GuardiaDepartment of Neurosurgery, University of Puerto Rico, School of Medicine, San Juan, PR, USA.
Juan C Vicenty-PadillaDepartment of Neurosurgery, University of Puerto Rico, School of Medicine, San Juan, PR, USA.
Patrick BrouwerDepartments of Neuroradiology and Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.
Matthias H SchmidtDivisions of Neuroradiology & Neurosurgery, QEII Health Sciences Centre, Dalhousie Medical School, Halifax, NS, USA.
Clemens SchirmerDepartments of Neurosurgery and Radiology, Geisinger Hospital, Danville, PA, USA.
Gwynedd E PickettDivisions of Neuroradiology & Neurosurgery, QEII Health Sciences Centre, Dalhousie Medical School, Halifax, NS, USA.
Tommy AnderssonDepartments of Neuroradiology and Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.
Michael SödermanDepartments of Neuroradiology and Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.
Thomas R MarottaDepartment of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA.
Hugo Cuellar-SaenzDepartment of Neurosurgery and Interventional Neuroradiology, Louisiana State University, Baton Rouge, LA, USA.
Ajith J ThomasDepartments of Neurological Surgery & Radiology, Mayo Clinic, Rochester, MN, USA.
Aman B PatelDepartment of Neuroradiology, Massachusetts General Hospital & Brigham and Women's Hospital, Boston, MA, USA.
Vitor Mendes PereiraDepartment of Neuroradiology, Massachusetts General Hospital & Brigham and Women's Hospital, Boston, MA, USA.
Nimer AdeebDepartment of Neurosurgery and Interventional Neuroradiology, Louisiana State University, Baton Rouge, LA, USA.
Flow diversion Multinational Observational cohort Device comparsion (FlowMOD) Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe comparative efficacy and safety of first-generation flow diverters (FDs), Pipeline Embolization Device (PED) (Medtronic, Irvine, California), Silk (Balt Extrusion, Montmorency, France), Flow Re-direction Endoluminal Device (FRED) (Microvention, Tustin, California), and Surpass Streamline (Stryker Neurovascular, Fremont, California), is not directly established and largely inferred. PURPOSE: This study aimed to compare the efficacy of different FDs in treating sidewall ICA intracranial aneurysms.

methodsWe conducted a retrospective review of prospectively maintained databases from eighteen academic institutions from 2009-2016, comprising 444 patients treated with one of four devices for sidewall ICA aneurysms. Data on demographics, aneurysm characteristics, treatment outcomes, and complications were analyzed. Angiographic and clinical outcomes were assessed using various imaging modalities and modified Rankin Scale (mRS). Propensity score weighting was employed to balance confounding variables. The data analysis used Kaplan-Meier curves, logistic regression, and Cox proportional-hazards regression.

resultsWhile there were no significant differences in retreatment rates, functional outcomes (mRS 0-1), and thromboembolic complications between the four devices, the probability of achieving adequate occlusion at the last follow-up was highest in Surpass device (HR: 4.59; CI: 2.75-7.66, p < 0.001), followed by FRED (HR: 2.23; CI: 1.44-3.46, p < 0.001), PED (HR: 1.72; CI: 1.10-2.70, p = 0.018), and Silk (HR: 1.0 ref. standard). The only hemorrhagic complications were with Surpass (1%).

conclusionAll the first-generation devices achieved good clinical outcomes and retreatment rates in treating ICA sidewall aneurysms. Prospective studies are needed to explore the nuanced differences between these devices in the long term.

Indexed as

Carotid Artery, InternalEndovascular ProceduresIntracranial AneurysmAdultAgedCerebral AngiographyEmbolization, TherapeuticFemaleHumansMaleMiddle AgedRetrospective StudiesStentsTreatment OutcomeFlow Diverter DevicesHemorrhagic ComplicationsIntracranial AneurysmsModified Rankin ScalePipeline Emboliza on DeviceThromboembolic Complications

Identifiers

PMID39023541

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.