Evidence map›Paper›PMID 39023392›Full record

ArticlePediatric pulmonology2024

Optimized algorithm for speed-of-sound-based infant sulfur hexafluoride multiple-breath washout measurements.

Florian Wyler, Thuvarakha Manogaran, Nathalie Monney, Yasmin Salem, Ruth Steinberg, Anne-Christianne Kentgens, Carvern Jacobs, Shaakira Chaya, Carla Rebeca da Silva Sena, Noëmi Künstle and 6 more

Abstract read
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In one paragraph

Article in Pediatric pulmonology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Florian WylerDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0002-1232-1392
Thuvarakha ManogaranDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0001-8824-1148
Nathalie MonneyDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0002-0627-6732
Yasmin SalemDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0001-8731-0885
Ruth SteinbergDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0003-4108-6085
Anne-Christianne KentgensDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0002-0171-9725
Carvern JacobsDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa.ORCID 0009-0003-4934-8550
Shaakira ChayaDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa.ORCID 0000-0002-7034-9289
Carla Rebeca da Silva SenaUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.ORCID 0000-0002-6424-7796
Noëmi KünstleUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.ORCID 0009-0000-8148-709X
Olga GorlanovaUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.ORCID 0000-0002-3153-7404
Sophie YammineDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0001-7720-3445
Diane M GrayDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa.ORCID 0000-0002-7712-6774
Urs FreyUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.ORCID 0000-0003-3773-2822
Marc-Alexander OestreichDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0001-9641-3691
Philipp LatzinDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0002-5239-1571

Funding

Bill and Melinda Gates Foundation OPP1017641Cystic Fibrosis SwitzerlandSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungSwiss Excellence GrantThrasher Foundation #9207Wellcome TrustWellcome Trust #098479/z/12/z
6 · The paper itself

Abstract

introductionMajor methodological issues with the existing algorithm (WBreath) used for the analysis of speed-of-sound-based infant sulfur hexafluoride (SF

methodsWe developed OASIS-a novel algorithm to analyze speed-of-sound-based infant SF

resultsIn vitro, OASIS managed to outperform WBreath at FRC measurement accuracy, lowering mean (SD) absolute error from 5.1 (3.2) % to 2.1 (1.6) % across volumes relevant for the infant age range, in variable temperature, respiratory rate, tidal volume and ventilation inhomogeneity conditions. We showed that changes in the input parameters to WBreath had a major impact on MBW results, a methodological drawback which does not exist in the new algorithm. OASIS produced more plausible results than WBreath in longitudinal tracking of lung clearance index (LCI), provided improved measurement stability in LCI over time, and improved comparability between centers. DISCUSSION: This new algorithm represents a meaningful advance in obtaining results from a legacy system of lung function measurement by allowing a single method to analyze measurements from different age groups and centers.

Indexed as

AlgorithmsSulfur HexafluorideBreath TestsFemaleFunctional Residual CapacityHumansInfantInfant, NewbornMaleRespiratory Function TestsSouth AfricaSwitzerlandSulfur Hexafluoridelung clearance indexOASISWBreath

Identifiers

PMID39023392
PMCPMC11601022

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.