ArticleJournal of animal science2024
Dietary probiotic based on a dual-strain Bacillus subtilis improves immunity, intestinal health, and growth performance of broiler chickens.
Article in Journal of animal science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Effects of dietary supplementation with fat powder with different n-6/n-3 polyunsaturated fatty acid ratios on the reproductive performance of sows and intestinal health of piglets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Combined Bifidobacterium bifidum and Bacillus toyonensis supplementation in drinking water improves productive efficiency, physiological status, and meat quality in broiler chickens.Poultry science · 2026Article
- Blautia Coccoides CML164 Improved Lipid and Energy Metabolism in Broiler Chickens Via Gut Microbiota Pathways.Probiotics and antimicrobial proteins · 2026Article
- Mechanisms of probiotic action in poultry gut: Colonization resistance, bioactive metabolites, quorum sensing activity, and immunomodulation.Poultry science · 2026Review
- Bacillus Probiotics in Broiler Nutrition: Mechanisms, Gut Health, Performance, and Practical Considerations.Probiotics and antimicrobial proteins · 2026Review
- A Bacillus-based direct-fed microbial impacted growth performance, immune cell presence, and in vivo Salmonella Enteritidis dissemination in growing broiler chickens.Poultry science · 2026Article
- Effects of dietary protease and protease-probiotic combination on growth performance, nutrient digestibility, and intestinal immune response in broiler chickens.Poultry science · 2026Article
- Bacillus-based probiotics and fermented products as alternatives to antibiotic growth promoters in poultry: Current perspectives.Poultry science · 2026Review
- Bacillus-derived antimicrobial peptides as alternatives to antibiotics in poultry: mechanisms, applications, and future prospects- a review.Archives of microbiology · 2026Review
- Evaluation of dietary Bacillus-based commercial probiotics in broiler chickens.Journal of animal science · 2026Article
- In vitro compatibility screening of Bacillus pumilus and Bacillus altitudinis strains with selected candidate prebiotics for in ovo application of synergistic synbiotics.Applied microbiology and biotechnology · 2025Article
- Supplementation ofAnimals : an open access journal from MDPI · 2025Article
- Nano-Encapsulated Cumin Oil andVeterinary sciences · 2025Article
- The Role of Probiotics in Enhancing Animal Health: Mechanisms, Benefits, and Applications in Livestock and Companion Animals.Animals : an open access journal from MDPI · 2025Review
- Antimicrobial and Nutritional Potentials ofInternational journal of molecular sciences · 2025Article
- Linarin alleviates colonic barrier dysfunction induced by enterotoxicFrontiers in immunology · 2025Article
- Effects of probiotics on gut microbiota in poultry.AIMS microbiology · 2025Review
- Effects ofAnimals : an open access journal from MDPI · 2024Article
- The Interactive Effects of Nutrient Density and Breed on Growth Performance and Gut Microbiota in Broilers.Animals : an open access journal from MDPI · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study investigated the effects of dietary probiotic of dual-strain Bacillus subtilis on production performance, intestinal barrier parameters, and microbiota in broiler chickens. In a randomized trial, male broiler chickens were allocated into 3 groups, a control group (basal diet), BS300 group (basal diet with 300 mg/kg of B. subtilis), and BS500 group (basal diet with 500 mg/kg of B. subtilis). The inclusion of 500 mg/kg of B. subtilis significantly reduced the feed conversion ratio by 4.55% during the starting phase. Both 300 and 500 mg/kg of B. subtilis supplementation increased jejunal villus height (by 17.89% and 24.8%, respectively) significantly and decreased jejunal crypt depth (by 27.2% and 31.9%, respectively) on day 21. The addition of 500 mg/kg of B. subtilis significantly elevated the gene expression of occludin on day 35. Moreover, of B. subtilis supplementation enhanced cytokine levels and immunoglobulins in both serum and jejunal mucosa. Microbial analysis indicated that B. subtilis increased the abundance of potential probiotics (Sutterella) and butyrate-producing bacteria (Lachnoclostridium, Tyzzerella, Anaerostipes, Clostridium_sensu_stricto_13, Prevotellaceae_NK3B31_group, and Lachnospiraceae_UCG-010). The abundances of Anaerostipes and Sutterella, are significantly correlated with growth performance and immune function. In conclusion, dietary supplementation with B. subtilis improved the growth performance, potentially through the regulation of immunity, intestinal barrier function, and microbiota in broilers. Notably, 500 mg/kg of B. subtilis exhibited more benefits for broilers compared to the 300 mg/kg.
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