Evidence map›Paper›PMID 39022779›Full record

ArticleIJTLD open2024

Mapping TB incidence across districts in Uganda to inform health program activities.

N J Henry, S Zawedde-Muyanja, R K Majwala, S Turyahabwe, R V Barnabas, R C Reiner, C E Moore, J M Ross

Abstract read
In one paragraph

Article in IJTLD open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

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10citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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  8. Mobility patterns, activity locations, and TB in Nairobi, Kenya.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2025
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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

N J HenryBig Data Institute, Li Ka Shing Centre for Information Discovery, University of Oxford, Oxford, UK.
S Zawedde-MuyanjaInfectious Diseases Institute, Makerere University, Kampala.
R K MajwalaUganda Ministry of Health, National Tuberculosis and Leprosy Program, Kampala, Uganda.
S TuryahabweUganda Ministry of Health, National Tuberculosis and Leprosy Program, Kampala, Uganda.
R V BarnabasDivision of Infectious Diseases, Massachusetts General Hospital, Boston, MA.
R C ReinerDepartment of Health Metrics Sciences, University of Washington, Seattle, WA.
C E MooreThe Centre for Neonatal and Paediatric Infection, Infection and Immunity Institute, St George's, University of London, London, UK.
J M RossDivision of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIdentifying spatial variation in TB burden can help national TB programs effectively allocate resources to reach and treat all people with TB. However, data limitations pose challenges for subnational TB burden estimation.

methodsWe developed a small-area modeling approach using geo-positioned prevalence survey data, case notifications, and geospatial covariates to simultaneously estimate spatial variation in TB incidence and case notification completeness across districts in Uganda from 2016-2019. TB incidence was estimated using 1) cluster-level data from the national 2014-2015 TB prevalence survey transformed to incidence, and 2) case notifications adjusted for geospatial covariates of health system access. The case notification completeness surface was fit jointly using observed case notifications and estimated incidence.

resultsEstimated pulmonary TB incidence among adults varied >10-fold across Ugandan districts in 2019. Case detection increased nationwide from 2016 to 2019, and the number of districts with case detection rates >70% quadrupled. District-level estimates of TB incidence were five times more precise than a model using TB prevalence survey data alone.

conclusionA joint spatial modeling approach provides useful insights for TB program operation, outlining areas where TB incidence estimates are highest and health programs should concentrate their efforts. This approach can be applied in many countries with high TB burden.

Indexed as

modellingTB control programTB preventiontuberculosis

Identifiers

PMID39022779
PMCPMC11249603

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.