Evidence map›Paper›PMID 39022742›Full record

ArticleMolecular therapy. Methods & clinical development2024

The postnatal injection of AAV9-FOXG1 rescues corpus callosum agenesis and other brain deficits in the mouse model of FOXG1 syndrome.

Shin Jeon, Jaein Park, Shibi Likhite, Ji Hwan Moon, Dongjun Shin, Liwen Li, Kathrin C Meyer, Jae W Lee, Soo-Kyung Lee

Abstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shin JeonDepartment of Biological Sciences, College of Arts and Sciences, FOXG1 Research Center, University at Buffalo, The State University of New York (SUNY), Buffalo, NY 14260, USA.
Jaein ParkDepartment of Biological Sciences, College of Arts and Sciences, FOXG1 Research Center, University at Buffalo, The State University of New York (SUNY), Buffalo, NY 14260, USA.
Shibi LikhiteThe Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.
Ji Hwan MoonDepartment of Biological Sciences, College of Arts and Sciences, FOXG1 Research Center, University at Buffalo, The State University of New York (SUNY), Buffalo, NY 14260, USA.
Dongjun ShinDepartment of Biological Sciences, College of Arts and Sciences, FOXG1 Research Center, University at Buffalo, The State University of New York (SUNY), Buffalo, NY 14260, USA.
Liwen LiDepartment of Biological Sciences, College of Arts and Sciences, FOXG1 Research Center, University at Buffalo, The State University of New York (SUNY), Buffalo, NY 14260, USA.
Kathrin C MeyerThe Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.
Jae W LeeDepartment of Biological Sciences, College of Arts and Sciences, FOXG1 Research Center, University at Buffalo, The State University of New York (SUNY), Buffalo, NY 14260, USA.
Soo-Kyung LeeDepartment of Biological Sciences, College of Arts and Sciences, FOXG1 Research Center, University at Buffalo, The State University of New York (SUNY), Buffalo, NY 14260, USA.

Funding

FoxG1-directed Gene Network in Forebrain Development and FoxG1 SyndromeR01NS100471 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LEE, SOO-KYUNG · 2017 to 2021
$2.4M
Transcription Factors Governing the Development of GHRH-neuronsR01NS118748 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LEE, JAE W, LEE, SOO-KYUNG · 2021 to 2024
$2.2M
Transcriptional Regulators of Motor Columnar SpecificationR01NS111760 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LEE, SOO-KYUNG · 2019 to 2023
$2.0M
NINDS NIH HHS R01 NS100471NINDS NIH HHS R01 NS111760NINDS NIH HHS R01 NS118748
6 · The paper itself

Abstract

Heterozygous mutations in the

Indexed as

AAV9corpus callosumdentate gyrusFOXG1gene therapymyelinationoligodendrocytes

Identifiers

PMID39022742
PMCPMC11253142

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.