Evidence map›Paper›PMID 39022616›Full record

ArticleBioactive materials2024

An injectable and coagulation-independent Tetra-PEG hydrogel bioadhesive for post-extraction hemostasis and alveolar bone regeneration.

Gang He, Yiwen Xian, Huajun Lin, Chengcheng Yu, Luyuan Chen, Zhihui Chen, Yonglong Hong, Chong Zhang, Decheng Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  13. The rising potential of tooth germ-derived stem cells and the future of oral rehabilitation.Journal of advanced periodontology & implant dentistry · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gang HeGuangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088 Xueyuan Avenue, Nanshan District, Shenzhen, Guangdong, 518055, China.
Yiwen XianGuangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088 Xueyuan Avenue, Nanshan District, Shenzhen, Guangdong, 518055, China.
Huajun LinDepartment of Maxillofacial Surgery, Shenzhen Hospital, Southern Medical University, No. 1333 New Road, Baoan District, Shenzhen, Guangdong, 518101, China.
Chengcheng YuDepartment of Maxillofacial Surgery, Shenzhen Hospital, Southern Medical University, No. 1333 New Road, Baoan District, Shenzhen, Guangdong, 518101, China.
Luyuan ChenDepartment of Maxillofacial Surgery, Shenzhen Hospital, Southern Medical University, No. 1333 New Road, Baoan District, Shenzhen, Guangdong, 518101, China.
Zhihui ChenDepartment of Maxillofacial Surgery, Shenzhen Hospital, Southern Medical University, No. 1333 New Road, Baoan District, Shenzhen, Guangdong, 518101, China.
Yonglong HongDepartment of Maxillofacial Surgery, Shenzhen Hospital, Southern Medical University, No. 1333 New Road, Baoan District, Shenzhen, Guangdong, 518101, China.
Chong ZhangGuangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088 Xueyuan Avenue, Nanshan District, Shenzhen, Guangdong, 518055, China.
Decheng WuGuangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088 Xueyuan Avenue, Nanshan District, Shenzhen, Guangdong, 518055, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Effective control of post-extraction hemorrhage and alveolar bone resorption is critical for successful extraction socket treatment, which remains an unmet clinical challenge. Herein, an injectable Tetra-PEG hydrogel that possesses rapid gelation, firm tissue adhesion, high mechanical strength, suitable degradability, and excellent biocompatibility is developed as a sutureless and coagulation-independent bioadhesive for the management of extraction sockets. Our results demonstrate that the rapid and robust adhesive sealing of the extraction socket by the Tetra-PEG hydrogel can provide reliable protection for the underlying wound and stabilize blood clots to facilitate tissue healing.

Indexed as

Alveolar bone regenerationAlveolar ridge preservationBlood clotsHemostatic hydrogelsHydrogel bioadhesives

Identifiers

PMID39022616
PMCPMC11252469

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.