Evidence map›Paper›PMID 39022390›Full record

ArticleOpen forum infectious diseases2024

Subcortical Brain Volumes and Neurocognitive Function in Children With Perinatal HIV Exposure: A Population-Based Cohort Study in South Africa.

Catherine J Wedderburn, Shunmay Yeung, Nynke A Groenewold, Andrea M Rehman, Sivenesi Subramoney, Jean-Paul Fouche, Shantanu H Joshi, Katherine L Narr, Nadia Hoffman, Annerine Roos and 4 more

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Article in Open forum infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Catherine J WedderburnDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-4887-1644
Shunmay YeungDepartment of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Nynke A GroenewoldThe Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Andrea M RehmanMedical Research Council Tropical Epidemiology Group, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Sivenesi SubramoneyDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Jean-Paul FoucheThe Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Shantanu H JoshiDepartment of Neurology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California, USA.
Katherine L NarrDepartment of Neurology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California, USA.
Nadia HoffmanDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Annerine RoosThe Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Diana M GibbMedical Research Council Clinical Trials Unit, University College London, London, United Kingdom.ORCID https://orcid.org/0000-0002-9738-5490
Heather J ZarDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Dan J SteinThe Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Kirsten A DonaldDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.

Funding

Cross-Cultural Assessment of FASDU24AA014811 · NIAAA · SAN DIEGO STATE UNIVERSITY · PI EDWARD P RILEY · 2003 to 2026
$13.1M
Tracking and Prediction of Early Brain-Face Biomarkers of Prenatal Alcohol Exposure from Neonates to ChildrenR01AA026834 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Kirsty Donald, Shantanu H. Joshi · 2018 to 2026
$3.8M
A neuroimaging study of 2 year old children with alcohol exposure compared to healthy unexposed controls embedded in a birth cohort studyR21AA023887 · NIAAA · UNIVERSITY OF CAPE TOWN · PI DONALD, KIRSTY · 2016 to 2017
$280k
NIAAA NIH HHS R01 AA026834NIAAA NIH HHS R21 AA023887NIAAA NIH HHS U24 AA014811Wellcome Trust
6 · The paper itself

Abstract

Background: Children who are HIV-exposed and uninfected (HEU) are at risk for early neurodevelopmental impairment. Smaller basal ganglia nuclei have been reported in neonates who are HEU compared to HIV-unexposed (HU); however, neuroimaging studies outside infancy are scarce. We examined subcortical brain structures and associations with neurocognition in children who are HEU. Methods: This neuroimaging study was nested within the Drakenstein Child Health Study birth cohort in South Africa. We compared (T1-weighted) magnetic resonance imaging-derived subcortical brain volumes between children who were HEU (n = 70) and HU (n = 92) at age 2-3 years using linear regression. Brain volumes were correlated with neurodevelopmental outcomes measured with the Bayley Scales of Infant and Toddler Development III. Results: Compared to HU children, on average children who were HEU had 3% lower subcortical grey matter volumes. Analyses of individual structures found smaller volume of the putamen nucleus in the basal ganglia (-5% difference, Conclusions: Overall, children who are HEU had a pattern of smaller subcortical volumes in the basal ganglia and hippocampal regions compared to HU children, which correlated with language function. Findings suggest that optimizing maternal perinatal HIV care is important for child brain development. Further studies are needed to investigate underlying mechanisms and long-term outcomes.

Indexed as

basal gangliachild brain structureHIV exposureimmune functionlanguage

Identifiers

PMID39022390
PMCPMC11253430

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.