Evidence map›Paper›PMID 39022362›Full record

ArticleACS pharmacology & translational science2024

Small-Molecule Disruptors of the Interaction between Calcium- and Integrin-Binding Protein 1 and Integrin α

Kalyan Golla, Adam Yasgar, Voddarahally N Manjuprasanna, Meghna U Naik, Bolormaa Baljinnyam, Alexey V Zakharov, Sankalp Jain, Ganesha Rai, Ajit Jadhav, Anton Simeonov and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A Hybrid Experimental and in silico Platform for ITPK1 Chemical Probe Discovery.SLAS discovery : advancing life sciences R & D · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kalyan GollaCardeza Center for Hemostasis, Thrombosis, and Vascular Biology, Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, United States.
Adam YasgarNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.ORCID https://orcid.org/0000-0001-7350-1402
Voddarahally N ManjuprasannaCardeza Center for Hemostasis, Thrombosis, and Vascular Biology, Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, United States.
Meghna U NaikCardeza Center for Hemostasis, Thrombosis, and Vascular Biology, Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, United States.
Bolormaa BaljinnyamNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.
Alexey V ZakharovNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.ORCID https://orcid.org/0000-0003-2466-1711
Sankalp JainNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.
Ganesha RaiNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.ORCID https://orcid.org/0000-0001-9763-9641
Ajit JadhavNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.
Anton SimeonovNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.
Ulhas P NaikCardeza Center for Hemostasis, Thrombosis, and Vascular Biology, Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, United States.ORCID https://orcid.org/0000-0001-7556-444X

Funding

ASK1 a novel regulator of platelet functionR01HL113188 · NHLBI · UNIVERSITY OF DELAWARE · PI NAIK, ULHAS P · 2013 to 2022
$3.4M
Regulation of Platelet Reactivity by S1P SignalingR01HL142959 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI NAIK, ULHAS P · 2019 to 2022
$2.1M
Identification of Calcium integrin binding protein 1 (CIB1) competitorZIATR000289 · NCATS · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · PI SIMEONOV, ANTON · 2017 to 2022
$953k
Intramural NIH HHS ZIA TR000289NHLBI NIH HHS R01 HL113188NHLBI NIH HHS R01 HL142959
6 · The paper itself

Abstract

Thrombosis, a key factor in most cardiovascular diseases, is a major contributor to human mortality. Existing antithrombotic agents carry a risk of bleeding. Consequently, there is a keen interest in discovering innovative antithrombotic agents that can prevent thrombosis without negatively impacting hemostasis. Platelets play crucial roles in both hemostasis and thrombosis. We have previously characterized calcium- and integrin-binding protein 1 (CIB1) as a key regulatory molecule that regulates platelet function. CIB1 interacts with several platelet proteins including integrin α

Identifiers

PMID39022362
PMCPMC11249646

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.