Evidence map›Paper›PMID 39022358›Full record

ArticleACS pharmacology & translational science2024

Interaction of the Atypical Tetracyclines Chelocardin and Amidochelocardin with Renal Drug Transporters.

Katharina Rox, Annett Kühne, Jennifer Herrmann, Rolf Jansen, Stephan Hüttel, Steffen Bernecker, Yohannes Hagos, Mark Brönstrup, Marc Stadler, Thomas Hesterkamp and 1 more

Abstract read
In one paragraph

Article in ACS pharmacology & translational science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Katharina RoxDepartment of Chemical Biology, Helmholtz Centre for Infection Research (HZI), 38124 Braunschweig, Germany.ORCID https://orcid.org/0000-0002-8020-1384
Annett KühnePortaCellTec Biosciences GmbH, 37079 Göttingen, Germany.
Jennifer HerrmannGerman Center for Infection Research (DZIF), partner site Braunschweig-Hannover, 38124 Braunschweig, Germany.ORCID https://orcid.org/0000-0003-3398-9938
Rolf JansenDepartment of Microbial Drugs, Helmholtz Centre for Infection Research (HZI), 38124 Braunschweig, Germany.
Stephan HüttelGerman Center for Infection Research (DZIF), partner site Braunschweig-Hannover, 38124 Braunschweig, Germany.
Steffen BerneckerDepartment of Microbial Drugs, Helmholtz Centre for Infection Research (HZI), 38124 Braunschweig, Germany.
Yohannes HagosPortaCellTec Biosciences GmbH, 37079 Göttingen, Germany.
Mark BrönstrupDepartment of Chemical Biology, Helmholtz Centre for Infection Research (HZI), 38124 Braunschweig, Germany.ORCID https://orcid.org/0000-0002-8971-7045
Marc StadlerGerman Center for Infection Research (DZIF), partner site Braunschweig-Hannover, 38124 Braunschweig, Germany.ORCID https://orcid.org/0000-0002-7284-8671
Thomas HesterkampGerman Center for Infection Research (DZIF), partner site Braunschweig-Hannover, 38124 Braunschweig, Germany.
Rolf MüllerGerman Center for Infection Research (DZIF), partner site Braunschweig-Hannover, 38124 Braunschweig, Germany.ORCID https://orcid.org/0000-0002-1042-5665

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance is expected to increase mortality rates by up to several million deaths per year by 2050 without new treatment options at hand. Recently, we characterized the pharmacokinetic (PK) and pharmacodynamic properties of two atypical tetracyclines, chelocardin (CHD) and amidochelocardin (CDCHD) that exhibit no cross-resistance with clinically used antibacterials. Both compounds were preferentially renally cleared and demonstrated pronounced effects in an ascending urinary tract infection model against

Identifiers

PMID39022358
PMCPMC11249637

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.