Evidence map›Paper›PMID 39022219›Full record

SynthesisFrontiers in pediatrics2024

A systematic review of prenatally diagnosed vein of Galen malformations: prenatal predictive markers and management from fetal life to childhood.

Lavinia Di Meglio, Giordana Sica, Paolo Toscano, Giuliana Orlandi, Luigi Manzo, Laura Letizia Mazzarelli, Carmine Sica, Aniello Di Meglio

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Time-of-flight: non-contrast vascular magnetic resonance imaging sequence in vein of Galen malformation.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026
    Article
  3. Microsurgical management of vein of Galen aneurysmal malformations.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
    Article
  4. Doppler Assessment of the Fetal Brain Circulation.Diagnostics (Basel, Switzerland) · 2026
    Review
  5. Review
  6. Review
  7. Article
  8. Routine 36-week scan: diagnosis of fetal abnormalities.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lavinia Di MeglioResidency School of Pediatrics, University of Rome Tor Vergata, Rome, Italy.
Giordana SicaUniversity of Medicine and Surgery Luigi Vanvitelli, Naples, Italy.
Paolo ToscanoDepartment of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine and Surgery Federico II of Naples, Naples, Italy.
Giuliana OrlandiDepartment of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine and Surgery Federico II of Naples, Naples, Italy.
Luigi ManzoDepartment of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine and Surgery Federico II of Naples, Naples, Italy.
Laura Letizia MazzarelliDepartment of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine and Surgery Federico II of Naples, Naples, Italy.
Carmine SicaDiagnositica Ecografia e Prenatale di A. Di Meglio, Naples, Italy.
Aniello Di MeglioDiagnositica Ecografia e Prenatale di A. Di Meglio, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Vein of Galen malformations (VGMs) account for less than 1% of all intracranial vascular malformations. However, in fetal and pediatric populations, they represent the most common vascular malformation of the brain. For the effective management of this condition, an optimal knowledge of its prenatal and postnatal clinical features is mandatory. Methods: Articles published between 1 January 2003 and 31 January 2024, reported in PubMed and EMBASE, were evaluated for a systematic review analyzing the prenatal and postnatal features and management of fetal VGMs. Results: Thirty-one papers reporting information on 51 prenatally diagnosed VGMs were included. The most common prenatal features were fetal hydrocephalus (39%) and cardiomegaly (56%). Postnatal data for 43 VGM cases are described. The overall mortality was 58.14%. In total, 77.78% of the survivors had normal development. Conclusions: Close follow-up and a multidisciplinary approach are mandatory to manage this condition. Our study aimed to provide a guide for gynecologists, neonatologists, cardiologists, and neuroradiologists.

Indexed as

fetusprenatal diagnosisvein of Galen aneurysmal malformationsvein of Galen malformationsVGAMVGMVGMsVGOM

Identifiers

PMID39022219
PMCPMC11251923

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.