Evidence map›Paper›PMID 39022118›Full record

ArticleInternational journal of particle therapy2024

Changes in Intratumor Blood Flow After Carbon-Ion Radiation Therapy for Early-Stage Breast Cancer.

Kenta Ohmatsu, Tokuhiko Omatsu, Noriyuki Okonogi, Yoko Ikoma, Kazutoshi Murata, Riwa Kishimoto, Takayuki Obata, Shigeru Yamada, Kumiko Karasawa

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In one paragraph

Article in International journal of particle therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kenta OhmatsuDepartment of Radiation Oncology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
Tokuhiko OmatsuQST Hospital, National Institutes for Quantum Science and Technology, Chiba, Japan.
Noriyuki OkonogiQST Hospital, National Institutes for Quantum Science and Technology, Chiba, Japan.
Yoko IkomaInstitute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan.
Kazutoshi MurataQST Hospital, National Institutes for Quantum Science and Technology, Chiba, Japan.
Riwa KishimotoQST Hospital, National Institutes for Quantum Science and Technology, Chiba, Japan.
Takayuki ObataInstitute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan.
Shigeru YamadaQST Hospital, National Institutes for Quantum Science and Technology, Chiba, Japan.
Kumiko KarasawaDepartment of Radiation Oncology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study aimed to quantify the changes in intratumoral blood flow after carbon-ion radiation therapy (CIRT) for early-stage breast cancer and analyze their clinical significance. Patients and Methods: We included 38 patients with early-stage breast cancer who underwent CIRT. Dynamic imaging was performed using a 3T superconducting magnetic resonance scanner to quantify the washin index (idx), which reflects contrast uptake, and washout idx, which reflects the rate of contrast washout from tumor tissue. The changes in the apparent diffusion coefficient, washin idx, and washout idx were examined before CIRT and at 1 and 3 months after treatment. Clinical factors and imaging features were examined using univariate and receiver operating characteristic curve analyses to identify factors predicting clinical complete response (cCR). Results: The median observation period after CIRT was 51 (range: 12-122) months. During the observation period, 31 of the 38 patients achieved cCR, and 22 achieved cCR within 12 months. Tumor size ( Conclusion: Tumor changes can be quantified early after CIRT using contrast-enhanced magnetic resonance imaging in patients with breast cancer. Washin idx values 1 and 3 months after CIRT were associated with cCR within 12 months post-CIRT.

Indexed as

Breast cancerCarbon-ion radiation therapyDynamic contrast-enhancedMagnetic resonance imagingQuantitative comparisons

Identifiers

PMID39022118
PMCPMC11252070

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.