ArticleiScience2024
Integrated single cell-RNA sequencing and Mendelian randomization for ischemic stroke and metabolic syndrome.
Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mendelian randomization studies on ischemic stroke: a field synopsis and systematic review.Journal of translational medicine · 2025Pooled it
- The association between the ZJU index and short-term prognosis in patients with acute ischemic stroke: a cohort study.Frontiers in endocrinology · 2026Article
- Negative association between oxidative balance score and stroke prevalence in US adults with metabolic syndrome: mediating roles of HDL-C and NHHR.European journal of medical research · 2025Article
- Article
- The interplay between metabolic health factors and stroke incidence in aging populations.Frontiers in endocrinology · 2025Article
- CSF1 mediating 3-hydroxyhexanoate in endometrial cancer: a Mendelian randomization study.Archives of medical science : AMS · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although more and more evidence has supported that metabolic syndrome (MS) is linked to ischemic stroke (IS), the molecular mechanism and genetic association between them has not been investigated. Here, we combined the existing single-cell RNA sequencing (scRNA-seq) data and mendelian randomization (MR) for stroke to understand the role of dysregulated metabolism in stroke. The shared hub genes were identified with machine learning and WGCNA. A total of six upregulated DEGs and five downregulated genes were selected for subsequent analyses. Nine genes were finally identified with random forest, Lasso regression, and XGBoost method as a potential diagnostic model. scRNA-seq also show the abnormal glycolysis level in most cell clusters in stroke and associated with the expression level of hub genes. The genetic relationship between IS and MS was verified with MR analysis. Our study reveals the common molecular profile and genetic association between ischemic stroke and metabolic syndrome.
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Registered trials
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