Evidence map›Paper›PMID 39021614›Full record

ArticleAdvanced functional materials2024

Regulating interparticle proximity in plasmonic nanosphere aggregates to enhance photoacoustic response and photothermal stability.

Myeongsoo Kim, Kelsey P Kubelick, Anthony M Yu, Don VanderLaan, Anamik Jhunjhunwala, Robert J Nikolai, Melissa Cadena, Jinhwan Kim, Stanislav Y Emelianov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Myeongsoo KimWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332, USA.
Kelsey P KubelickWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332, USA.
Anthony M YuWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332, USA.
Don VanderLaanWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332, USA.
Anamik JhunjhunwalaWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332, USA.
Robert J NikolaiWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332, USA.
Melissa CadenaWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332, USA.
Jinhwan KimWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332, USA.
Stanislav Y EmelianovWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332, USA.

Funding

Trimodal Vitality Imaging of Neural Progenitor Cells in the Spinal CordR01NS117613 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI EMELIANOV, STANISLAV Y · 2020 to 2025
$3.0M
Image-guided cancer therapy using heat activatable CAR T cellsR01EB032822 · NIBIB · GEORGIA INSTITUTE OF TECHNOLOGY · PI EMELIANOV, STANISLAV Y, KWONG, GABRIEL A · 2022 to 2025
$2.6M
Background-free molecular imaging using modulated photoacoustics and targeted contrast agentR01EB028916 · NIBIB · GEORGIA INSTITUTE OF TECHNOLOGY · PI DICKSON, ROBERT M, EMELIANOV, STANISLAV Y · 2020 to 2023
$2.4M
Magnetic Steering and Longitudinal Visualization of Stem Cells for Trabecular Meshwork Therapy in GlaucomaR01EY030071 · NEI · GEORGIA INSTITUTE OF TECHNOLOGY · PI EMELIANOV, STANISLAV Y, ETHIER, C ROSS · 2019 to 2022
$2.3M
Nanoparticle-augmented image-guided CAR T therapy and post-treatment assessmentR00CA263016 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KIM, JINHWAN · 2023 to 2025
$744k
Nanoparticle-augmented image-guided CAR T therapy and post-treatment assessmentK99CA263016 · NCI · GEORGIA INSTITUTE OF TECHNOLOGY · PI KIM, JINHWAN · 2022 to 2022
$133k
In vivo Photoacoustic Monitoring of Stem Cell Differentiation to Cancer Associated FibroblastsF31AG082500 · NIA · GEORGIA INSTITUTE OF TECHNOLOGY · PI JHUNJHUNWALA, ANAMIK · 2024 to 2025
$99k
NCI NIH HHS K99 CA263016NCI NIH HHS R00 CA263016NEI NIH HHS R01 EY030071NIA NIH HHS F31 AG082500NIBIB NIH HHS R01 EB028916NIBIB NIH HHS R01 EB032822NINDS NIH HHS R01 NS117613
6 · The paper itself

Abstract

Designing plasmonic nanoparticles for biomedical photoacoustic (PA) imaging involves tailoring material properties at the nanometer scale. A key in developing plasmonic PA contrast nanoagents is to engineer their enhanced optical responses in the near-infrared wavelength range, as well as heat transfer properties and photostability. This study introduces anisotropic plasmonic nanosphere aggregates with close interparticle proximity as photostable and efficient contrast agent for PA imaging. Silver (Ag), among plasmonic metals, is particularly attractive due to its strongest optical response and highest heat conductivity. Our results demonstrate that close interparticle proximity in silver nanoaggregates (AgNAs), spatially confined within a polymer shell layer, leads to blackbody-like optical absorption, resulting in robust PA signals through efficient pulsed heat generation and transfer. Additionally, our AgNAs exhibit a high photodamage threshold highlighting their potential to outperform conventional plasmonic contrast agents for high-contrast PA imaging over multiple imaging sessions. Furthermore, we demonstrate the capability of the AgNAs for molecular PA cancer imaging

Indexed as

exogenous contrast agentsheat transferinterparticle proximityPhotoacousticsphotostabilityplasmonic nanoaggregatespulsed heat generation

Identifiers

PMID39021614
PMCPMC11250694

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.