ArticleIJTLD open2024
Cost and cost-effectiveness of BPaL regimen used in drug-resistant TB treatment in the Philippines.
Article in IJTLD open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Orchestrating faster access to products of non-profit R&D: a case study of a novel regimen for drug-resistant tuberculosis.BMJ global health · 2026Article
- An economic analysis of BPaL for multidrug-resistant TB in South Africa and the Philippines.IJTLD open · 2025Article
- Pakistan's path forward in DR-TB management: insights from global implementation of BPaL/BPaLM regimen.Annals of medicine and surgery (2012) · 2025Article
- Comparing cost-effectiveness of short-course regimens for drug-resistant tuberculosis treatment in India.International journal of technology assessment in health care · 2025Article
- Urgent request for pretomanid label expansion to align with WHO guidelines and improve treatment accessibility and efficacy.IJTLD open · 2025Article
- The catastrophic cost of TB care: Understanding costs incurred by individuals undergoing TB care in low-, middle-, and high-income settings - A systematic review.PLOS global public health · 2025Article
- Impact of financial support on treatment outcomes of multidrug-resistant tuberculosis: A population-based, retrospective cohort study in Shanghai, China.Journal of clinical tuberculosis and other mycobacterial diseases · 2024Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundIn 2022, the WHO announced that the 6-month BPaL/M regimen should be used for drug-resistant TB (DR-TB). We estimate the patient and provider costs of BPaL compared to current standard-of-care treatment in the Philippines.
methodsPatients on BPaL under operational research, or 9-11-month standard short oral regimen (SSOR) and 18-21-month standard long oral regimen (SLOR) under programmatic conditions were interviewed using the WHO cross-sectional TB patient cost tool. Provider costs were assessed through a bottom-up and top-down costing analysis.
resultsTotal patient costs per treatment episode were lowest with BPaL (USD518.0) and increased with use of SSOR (USD825.8) and SLOR (USD1,023.0). Total provider costs per successful treatment were lowest with BPaL (USD1,994.5) and increased with SSOR (USD3,121.5) and SLOR (USD10,032.4). Compared to SSOR, BPaL treatment was cost-effective at even the lowest willingness to pay threshold. As expected, SLOR was the costliest and least effective regimen.
conclusionsCosts incurred by patients on BPaL were 37% (95% CI 22-56) less than SSOR and 50% (95% CI 32-68) less than SLOR, while providers could save 36% (95% CI 21-56) to 80% (95% CI 64-93) per successful treatment, respectively. The study shows that treatment of DR-TB with BPaL was cost-saving for patients and cost-effective for the health system.
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