Evidence map›Paper›PMID 39021433›Full record

ArticleJournal of immunology research2024

C5aR2 Deficiency Lessens C5aR1 Distribution and Expression in Neutrophils and Macrophages.

Ting Zhang, Ning Ma, Jiaxing Wang, Xiaoyun Min, Linlin Wei, Ke Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ting ZhangDepartment of Pathology The Second Affiliated Hospital School of Medicine Xi'an Jiaotong University, Xi'an 710004, China.ORCID https://orcid.org/0000-0001-6413-4436
Ning MaCore Research Laboratory The Second Affiliated Hospital School of Medicine Xi'an Jiaotong University, Xi'an 710004, China.ORCID https://orcid.org/0000-0003-2576-1933
Jiaxing WangInstitute of Hematology School of Medicine Northwest University, Xi'an 710069, China.ORCID https://orcid.org/0000-0001-9834-6680
Xiaoyun MinCore Research Laboratory The Second Affiliated Hospital School of Medicine Xi'an Jiaotong University, Xi'an 710004, China.ORCID https://orcid.org/0000-0001-5718-2026
Linlin WeiCore Research Laboratory The Second Affiliated Hospital School of Medicine Xi'an Jiaotong University, Xi'an 710004, China.ORCID https://orcid.org/0000-0003-4036-0660
Ke LiCore Research Laboratory The Second Affiliated Hospital School of Medicine Xi'an Jiaotong University, Xi'an 710004, China.ORCID https://orcid.org/0000-0002-0459-5377

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As another receptor for complement activation product C5a, C5aR2 has been paid much attention these years. Although controversial and complex, its specific signals or roles in modulating the classic receptor C5aR1 have been investigated and gradually revealed. The hypothesis of the heterodimer of C5aR1 and C5aR2 has also been suggested and observed under extremely high C5a concentrations. In this article, we tried to investigate whether C5aR2 would affect C5aR1 expression under normal or inflammatory conditions in WT and

Indexed as

MacrophagesNeutrophilsPeritonitisReceptor, Anaphylatoxin C5aAnimalsComplement C5aDisease Models, AnimalImmunity, InnateMiceMice, Inbred C57BLMice, KnockoutC5ar1 protein, mouseC5ar2 protein, mouseComplement C5aReceptor, Anaphylatoxin C5a

Identifiers

PMID39021433
PMCPMC11254461

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.