Evidence map›Paper›PMID 39021183›Full record

ReviewCurrent neuropharmacology2024

Ischemic Stroke and Autophagy: The Roles of Long Non-Coding RNAs.

Longqiang Ouyang, Wenyan Xia, Ameen Abdulhasan Al-Alwany, Reena Gupta, Ibrokhim Sapaev, Sami G Almalki, Saud Almawash, Rand Ali Ziyad, Ahmed Hussien Alawadi, Ali Alsalamy

Abstract readReview
In one paragraph

Review in Current neuropharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Longqiang OuyangDepartment of Neurosurgery, The First Affiliated Hospital, Gannan Medical University, Ganzhou, Jiangxi, China.
Wenyan XiaDepartment of Endocrinology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
Ameen Abdulhasan Al-AlwanyDepartment of Medicine, College of Medicine, Baghdad University, Baghdad, Iraq.
Reena GuptaInstitute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, 281406, India.
Ibrokhim SapaevNew Uzbekistan University, Tashkent, Uzbekistan.
Sami G AlmalkiDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Majmaah 11952, Saudi Arabia.
Saud AlmawashDepartment of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra, Saudi Arabia.
Rand Ali ZiyadCollege of Pharmacy, National University of Science and Technology, Dhi Qar, Iraq.
Ahmed Hussien AlawadiCollege of Technical Engineering, The Islamic University, Najaf, Iraq.
Ali AlsalamyCollege of Technical Engineering, Imam Ja'afar Al-Sadiq University, Al-Muthanna 66002, Iraq.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke is a significant cause of morbidity and mortality worldwide. Autophagy, a process of intracellular degradation, has been shown to play a crucial role in the pathogenesis of ischemic stroke. Long non-coding RNAs (lncRNAs) have emerged as essential regulators of autophagy in various diseases, including ischemic stroke. Recent studies have identified several lncRNAs that modulate autophagy in ischemic stroke, including MALAT1, MIAT, SNHG12, H19, AC136007. 2, C2dat2, MEG3, KCNQ1OT1, SNHG3, and RMRP. These lncRNAs regulate autophagy by interacting with key proteins involved in the autophagic process, such as Beclin-1, ATG7, and LC3. Understanding the role of lncRNAs in regulating autophagy in ischemic stroke may provide new insights into the pathogenesis of this disease and identify potential therapeutic targets for its treatment.

Indexed as

AutophagyIschemic StrokeRNA, Long NoncodingAnimalsHumansRNA, Long NoncodingautophagyIschemic strokelong non-coding RNAspathogenesispotential therapeutic targets.treatment

Identifiers

PMID39021183
PMCPMC11519825

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.