ArticleRadiation oncology (London, England)2024
Treatment outcomes of surgery followed by short-course every other day radiotherapy in keloid.
Article in Radiation oncology (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Efficacy of peri-operative high-dose-rate interstitial brachytherapy in keloids: Can we scare the bad scar?Journal of contemporary brachytherapy · 2026Article
- Adjuvant Radiotherapy Following Surgical Excision of Keloids: A Systematic Review of Dose, Fractionation, and Recurrence.Life (Basel, Switzerland) · 2026Review
- Post-surgical electron beam radiotherapy for prevention of keloid recurrence: A retrospective study of 619 cases demonstrating low recurrence (6.5%) with optimised 18 Gy in two fractions.Clinical medicine (London, England) · 2026Article
- Application of Brachytherapy in Postoperative Treatment of Keloid-Prone Patients.Journal of cosmetic dermatology · 2026Article
- Development of Malignant Peripheral Nerve Sheath Tumor After Keloid Treatment.Plastic and reconstructive surgery. Global open · 2025Article
- Wound Infection After Keloid Excision and Adjuvant Radiotherapy: Two Case Reports and Literature Review.Clinical, cosmetic and investigational dermatology · 2025Article
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Abstract
backgroundPostoperative radiotherapy can significantly reduce keloid recurrence. However, consensus on the optimal radiotherapy dose and treatment schedule remains elusive. This study aims to evaluate the effectiveness of surgery followed by a short-course of radiotherapy administered every other day for keloid treatment. MATERIALS/
methodsWe conducted a retrospective analysis of 498 patients with keloids treated at our institution between January 2010 and December 2017. All patients underwent electron beam irradiation at a dose of 16 Gy, delivered in four fractions every other day, starting within 24 h post-surgery. The primary endpoint of the study was the local control rate.
resultsA total of 130 (26.5%) keloids recurred after a median follow-up of 68.1months (42.6-129.9 months). The local control rates at 1 year, 3 years and 5 years for all patients were 89.5%, 82.5% and 81%, respectively. The highest recurrence rate was observed in keloids located in the chest region (50.8%), followed by the suprapubic (47.8%), head and neck (38.8%), limbs (33.3%) and ear (14%). Both multivariate and univariate analyses identified the presence of pain and or pruritus as an independently prognostic factor for keloid recurrence (p<0.0001). The local control rates at 1-year, 3-years and 5-years for patients with or without symptom of pain or pruritus were 45% vs. 98.8%, 12.5% vs. 95.9%, and 8.8% vs. 95%, respectively (HR:37.829, 95%CI: 24.385-58.686, p<0.001). In the ear keloid subgroup, the 1-year, 3-year and 5-year local control rates for patients with pruritus were significantly lower than those without pain or pruritus (60.0% vs. 97.9%, 26.7% vs. 94.7%, 26.7% vs. 94.3%, HR:30.209, 95% CI:14.793-61.69, p<0.001). The same results were found in other location(p<0.001). During treatment and follow-up, two patients experienced infections, and one patient developed a cutaneous fibroblastoma.
conclusionThis study suggests that a combination of surgery followed by short-course, every-other-day radiotherapy can yield satisfactory local control rates for keloids. Pain and or pruritus symptom was an independently prognostic factors for recurrence of keloid. To further validate these results, a prospective randomized controlled trial is recommended.
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