Evidence map›Paper›PMID 39020358›Full record

ArticleBMC musculoskeletal disorders2024

Investıgatıon of the effects of treatment with enoxaparın sodıum and hyperbarıc oxygen therapy on the recovery of rats wıth achılles tendon rupture.

Cafer Erman Aytekin, Yalcın Turhan, Zekeriya Okan Karaduman, Mehmet Arıcan, Sönmez Saglam, Sinem Kantarcıoglu Coskun, Veysel Uludag

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. In Vitro Modulation of Murine Tenocyte Behavior by Hyperbaric Oxygen Therapy.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cafer Erman AytekinFaculty of Medicine, Department of Orthopaedics and Traumatology, Duzce University, Duzce, Türkiye.
Yalcın TurhanFaculty of Medicine, Department of Orthopaedics and Traumatology, Duzce University, Duzce, Türkiye.
Zekeriya Okan KaradumanFaculty of Medicine, Department of Orthopaedics and Traumatology, Duzce University, Duzce, Türkiye. karadumano@hotmail.com.
Mehmet ArıcanFaculty of Medicine, Department of Orthopaedics and Traumatology, Duzce University, Duzce, Türkiye.
Sönmez SaglamFaculty of Medicine, Department of Orthopaedics and Traumatology, Duzce University, Duzce, Türkiye.
Sinem Kantarcıoglu CoskunFaculty of Medicine, Department of Pathology, Duzce University, Duzce, Türkiye.
Veysel UludagFaculty of Medicine, Department of Orthopaedics and Traumatology, Duzce University, Duzce, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn this study, we aimed to investigate the effects of hyperbaric oxygen therapy and enoxaparin sodium, which are known to accelerate bone tissue healing as well as tendon and soft tissue healing, on the healing of Achilles tendon rupture.

methodsThirty-six rats were used in the present study. All rats were divided into groups of nine. The groups were the enoxaparin sodium group, enoxaparin sodium and hyperbaric oxygen group, hyperbaric oxygen group and control group. After 21 days, the process was completed, and the rats were sacrificed. Achilles tendon samples were evaluated histopathologically.

resultsThe groups were compared according to the results of statistical analysis based on the histopathological data. There was no significant difference between the groups in terms of acute inflammation (p = 0.785) or chronic inflammation (p = 0.827) scores, but there were significant differences in neovascularization (p = 0.009), proliferation (p < 0.001) and fibrosis (p = 0.006) scores.

conclusionOur study showed that the use of enoxaparin sodium and hyperbaric oxygen had a positive effect on the healing of the Achilles tendon. Based on these results, we believe that the use of enoxaparin sodium and hyperbaric oxygen therapy after Achilles tendon rupture will be beneficial for healing and preventing complications.

Indexed as

Achilles TendonEnoxaparinHyperbaric OxygenationTendon InjuriesWound HealingAnimalsDisease Models, AnimalMaleRatsRats, Sprague-DawleyRats, WistarRecovery of FunctionRuptureEnoxaparinAchilles tendon ruptureEnoxaparin sodiumHyperbaric oxygen therapyRat

Identifiers

PMID39020358
PMCPMC11256415

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.