Observational studyBMC infectious diseases2024
Epidemiological and microbial trends of infective endocarditis in western Norway: a 7-year prospective observational study.
Observational study in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The Use of Oritavancin as Consolidation Therapy for Infective Endocarditis Caused byOpen forum infectious diseases · 2025Trial
- Recurrent Prosthetic Valve Endocarditis With Aortomitral Curtain Destruction in an Elderly Patient.JACC. Case reports · 2026Article
- Changing Epidemiology, Healthcare-Associated Infections, and Outcomes in Infective Endocarditis: A Five-Year Retrospective Study from a Tertiary Cardiovascular Center.Medicina (Kaunas, Lithuania) · 2026Article
- Infective endocarditis after transcatheter aortic valve implantation: risk factors and mortality impact in a case-control study.Open heart · 2026Article
- Real-World Infective Endocarditis in a Regional Hospital: Clinical Severity, Guideline Adherence, and Determinants of In-Hospital Outcomes.Journal of clinical medicine · 2026Article
- Health-Related Quality of Life of Patients With Infective Endocarditis-A Cross-Sectional Study Based on Data From the DERIVE Cohort.Open forum infectious diseases · 2026Article
- Oritavancin in Complicated Bloodstream Infections and Endocarditis in Spain and Italy (ORIBAC Study): A Retrospective Multicenter Observational Study.Infectious diseases and therapy · 2026Article
- Article
- Global, regional, and national burden of endocarditis, 1990-2021: a systematic analysis of the GBD 2021 study.BMC cardiovascular disorders · 2025Article
- Exploring sex differences in infective endocarditis - a prospective, observational study from Western Norway.BMC cardiovascular disorders · 2025Observational
- Clinical Characterization of Pathogens, Risk Factors and Quality of Life in an Observational Study of Native vs. Prosthetic Aortic Valve Endocarditis Surgery.Life (Basel, Switzerland) · 2024Article
- Beyond antibiotic prophylaxis: A scoping review of infective endocarditis prevention in the device era.International journal of immunopathology and pharmacologyArticle
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Authors and funding
8 authors.
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Abstract
backgroundIn this prospective, observational study, we aimed to investigate epidemiologic and microbial trends of infective endocarditis in western Norway.
methodsClinical and microbiological characteristics of 497 cases of infective endocarditis from 2016 through 2022 were investigated. Categorical data were analysed using Chi-squared tests. Survival data were analysed using multiple Cox regression and reported using hazard ratios.
resultsThe mean age was 67 years, and 74% were men. The annual incidence rates varied from 10.4 to 14.1 per 100,000 inhabitants per year. Infective endocarditis on native valves was observed in 257 (52%) of the cases, whereas infective endocarditis on prosthetic valves and/or cardiac implantable electronic devices was observed in 240 (48%) of the cases: infection on surgically implanted bioprostheses was observed in 124 (25%) of the patients, infection on transcatheter aortic valve implantation was observed in 47 (10%) patients, and infection on mechanical valves was observed in 34 (7%) cases. Infection related to cardiac implantable electronic devices was observed in a total of 50 (10%) cases. Staphylococcus aureus and viridans streptococci were the most common microbial causes, and isolated in 145 (29%) and 130 (26%) of the cases, respectively. Enterococcal endocarditis showed a rising trend during the study period and constituted 90 (18%) of our total cases of infective endocarditis, and 67%, 47%, and 26% of the cases associated with prosthetic material, transcatheter aortic valve implantation and cardiac implantable electronic devices, respectively. There was no significant difference in 90-day mortality rates between the native valve endocarditis group (12%) and the group with infective endocarditis on prosthetic valves or cardiac implants (14%), p = 0.522. In a model with gender, age, people who inject drugs, microbiology and type of valve affected, only advanced age was significantly associated with fatal outcome within 90 days.
conclusionsThe incidence of infective endocarditis, and particularly enterococcal endocarditis, increased during the study period. Enterococci appeared to have a particular affinity for prosthetic cardiac material. Advanced age was the only independent risk factor for death within 90 days.
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