ArticleStress (Amsterdam, Netherlands)2024
Genotypic variation in the promoter region of the CRH-248 gene interacts with early rearing experiences to disrupt the development of the HPA axis in infant rhesus macaques (
Elizabeth K Wood, S Andrew Aston, Patrick H O'Connell, Elia Hafen, Andrea N Skowbo, Melanie L Schwandt, Stephen G Lindell, Ellie Smith, Miranda Johnson, Zachary Baron and 5 more
Abstract read
In one paragraphArticle in Stress (Amsterdam, Netherlands), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
15 authors.
Patrick H O'ConnellDepartment of Psychology, Brigham Young University, Provo, UT, USA.
Elia HafenDepartment of Neuroscience, Brigham Young University, Provo, UT, USA.
Andrea N SkowboDepartment of Psychology, Brigham Young University, Provo, UT, USA.
Melanie L SchwandtLaboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, Poolesville, MD, USA.ORCID 0000-0002-8355-4900 Stephen G LindellLaboratory of Neurogenetics, Section of Comparative Behavioral Genomics, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD, USA.
Christina S BarrLaboratory of Neurogenetics, Section of Comparative Behavioral Genomics, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD, USA.
Stephen J SuomiLaboratory of Comparative Ethology, National Institute of Child Health and Human Development, Poolesville, MD, USA.
David GoldmanLaboratory of Neurogenetics, Section of Comparative Behavioral Genomics, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD, USA.ORCID 0000-0002-1724-5405 Funding
Integrative genetics of behavior with high throughput technologiesZIAAA000301 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI GOLDMAN, DAVID · 2009 to 2025
$68.6MDevelopmental Continuity Of Individual Differences In Reactivity In MonkeysZIAHD001106 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI SUOMI, STEPHEN J. · 2009 to 2018
$8.8MEarly Environments and Genetic Effects on Alcohol Abuse and Associated BehaviorZ01AA000214 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI HEILIG, MARKUS · 2002 to 2008
$2.8MDEVELOPMENTAL CONTINUITY OF INDIVIDUAL DIFFERENCES IN RHESUS MONKEY REACTIVITYZ01HD001106 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI SUOMI, STEPHEN J. · 1985 to 2008
$1.9MStress, HPA Axis Response, Monoamine Functioning and AlcZ01AA000077 · NIAAA · ALCOHOL ABUSE AND ALCOHOLISM · PI HIGLEY, JAMES DEE · 1994 to 2006
–Intramural NIH HHS Z01 AA000077Intramural NIH HHS Z01 AA000214Intramural NIH HHS Z01 HD001106Intramural NIH HHS ZIA HD001106
6 · The paper itselfAbstract
Aberrant functioning of the hypothalamic-pituitary-adrenal (HPA) axis is a hallmark of conditions such as depression, anxiety disorders, and post-traumatic stress disorder. Early-life adversity and genetic variation can interaction to disrupt HPA axis regulation, potentially contributing to certain forms of psychopathology. This study employs a rhesus macaque model to investigate how early parental neglect interacts with a single nucleotide polymorphism within the promoter region of the corticotropin-releasing hormone (CRH-248) gene, impacting the development of the HPA axis. For the initial six months of life, 307 rhesus monkey infants (
Indexed as
Corticotropin-Releasing HormoneHydrocortisoneHypothalamo-Hypophyseal SystemMacaca mulattaPituitary-Adrenal SystemPolymorphism, Single NucleotidePromoter Regions, GeneticAdrenocorticotropic HormoneAnimalsFemaleGene-Environment InteractionGenotypeMaleMaternal DeprivationStress, PsychologicalAdrenocorticotropic HormoneCorticotropin-Releasing HormoneHydrocortisoneACTHcortisolCRH genotypeexperience-expectant braingene by environment interactionMacaca mulattarearing conditionrhesus macaquestress response
Identifiers
PMID39020286
PMCPMC11279524
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