ArticleNature2024
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan.
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers, 3 of them syntheses that pooled it.
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153citing papers in PubMed, 3 pooled it
–field-weighted citation impact
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
153 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Genome-wide meta-analysis across East Asian and European populations provides insights into the molecular basis of lung cancer.Genome medicine · 2026Pooled it
- Frailty in maintenance hemodialysis: a systematic review and meta-analysis of prevalence and risk factors.International urology and nephrology · 2026Pooled it
- Rejuvenation of Bone Marrow Mesenchymal Stem Cells: Mechanisms and Their Application in Senile Osteoporosis Treatment.Biomolecules · 2025Pooled it
- The "Reducing Inflammation for Greater Health Trial (RIGHT)" Study-Concept, Rationale, and Design.Journal of the American Geriatrics Society · 2026Trial
- Age-associated differences in XBB.1.5 trivalent booster vaccine-induced adaptive responses revealed by single-cell RNA sequencing.Emerging microbes & infections · 2026Article
- Dermal fibroblasts cultured from aged human skin display a pro-inflammatory phenotype.Journal of cell communication and signaling · 2026Article
- Article
- Bone aging: a paradigm of multiscale degeneration and targeted rejuvenation.Bone research · 2026Review
- Interleukin-11 Signaling in Liver Disease: Mechanisms, Cellular Crosstalk, and Therapeutic Potential.Biomolecules · 2026Review
- Strengthening muscle for healthy ageing: innovative treatments for sarcopenia.Nature reviews. Drug discovery · 2026Review
- Submolecular modulation of PIEZO1 mechanotransduction with wireless tailor-made nanoswitches.Bioactive materials · 2026Article
- A Mechanism-Based Framework for Anti-Aging Strategies: From Metabolic Regulation to Senotherapy and Stem Cell-Based Interventions.Aging cell · 2026Review
- Stress Hyperglycemia Drives CD4Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Idiopathic pulmonary fibrosis and interleukins: a bibliometric analysis [1999-2025].Journal of thoracic disease · 2026Article
- Mechanisms and therapeutic potential of AMPK signaling pathway in the regulation of lipid metabolism.Molecular biology reports · 2026Review
- Beyond fibrosis: Emerging role of IL-11 in regulating innate and adaptive immune cell plasticity.Molecular biology reports · 2026Review
- Cardiac effects of prolonged recombinant human interleukin-11 treatment in severe thrombocytopenia: a retrospective cohort study.BMC pharmacology & toxicology · 2026Article
- Targeting interleukin-11 to slow ovarian aging.Nature aging · 2026Article
- Modulating IL-11-dependent matrix stiffness to delay ovarian aging.Nature aging · 2026Article
- Review
93 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
26 authors.
Anissa A Widjaja *Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore. anissa.widjaja@duke-nus.edu.sg.ORCID 0000-0001-9404-7608
Wei-Wen Lim *Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.ORCID 0000-0003-0311-943X
Sivakumar ViswanathanCardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.
Sonia ChothaniCardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.
Ben CordenNational Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.
Cibi Mary DasanCardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.
Joyce Wei Ting GohCardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.
Radiance LimCardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.ORCID 0000-0002-9865-7064
Brijesh K SinghCardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.ORCID 0000-0003-4615-3988
Jessie TanNational Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.
Chee Jian PuaNational Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.ORCID 0000-0003-4683-3043
Sze Yun LimCardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.
Eleonora AdamiCardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
Sebastian SchaferCardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.ORCID 0000-0002-6909-8275
Benjamin L GeorgeCardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.
Mark SweeneyMRC Laboratory of Medical Sciences, London, UK.ORCID 0000-0001-5098-0076
Chen XieNational Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.
Madhulika TripathiCardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.
Natalie A SimsBone Biology and Disease Unit, St Vincent's Institute of Medical Research, Melbourne, Victoria, Australia.ORCID 0000-0003-1421-8468
Norbert HübnerCardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.ORCID 0000-0002-1218-6223
Enrico PetrettoCardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.ORCID 0000-0003-2163-5921
Dominic J WithersMRC Laboratory of Medical Sciences, London, UK.ORCID 0000-0002-8009-7521
Lena HoCardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.ORCID 0000-0002-9358-621X
Jesus GilMRC Laboratory of Medical Sciences, London, UK.ORCID 0000-0002-4303-6260
David CarlingMRC Laboratory of Medical Sciences, London, UK.ORCID 0000-0002-2316-1830
Stuart A CookCardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore. stuart.cook@duke-nus.edu.sg.ORCID 0000-0001-6628-194X
Funding
Wellcome Trust
Abstract
For healthspan and lifespan, ERK, AMPK and mTORC1 represent critical pathways and inflammation is a centrally important hallmark
Indexed as
AgingInterleukin-11LongevitySignal TransductionAMP-Activated Protein KinasesAnimalsExtracellular Signal-Regulated MAP KinasesFemaleFrailtyHumansInflammationInterleukin-11 Receptor alpha SubunitMaleMechanistic Target of Rapamycin Complex 1MiceMice, Inbred C57BLAMP-Activated Protein KinasesExtracellular Signal-Regulated MAP KinasesIL11 protein, humanIl11ra1 protein, mouseInterleukin-11Interleukin-11 Receptor alpha SubunitMechanistic Target of Rapamycin Complex 1
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.