Evidence map›Paper›PMID 39020174›Full record

ArticleNature2024

Tubulin code eraser CCP5 binds branch glutamates by substrate deformation.

Jiayi Chen, Elena A Zehr, James M Gruschus, Agnieszka Szyk, Yanjie Liu, Martin E Tanner, Nico Tjandra, Antonina Roll-Mecak

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiayi ChenCell Biology and Biophysics Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.ORCID 0000-0002-1016-4661
Elena A ZehrCell Biology and Biophysics Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
James M GruschusBiochemistry and Biophysics Center, National Heart, Lung and Blood Institute, Bethesda, MD, USA.
Agnieszka SzykCell Biology and Biophysics Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Yanjie LiuDepartment of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada.
Martin E TannerDepartment of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-3224-3491
Nico TjandraBiochemistry and Biophysics Center, National Heart, Lung and Blood Institute, Bethesda, MD, USA.
Antonina Roll-MecakCell Biology and Biophysics Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA. Antonina@mail.nih.gov.ORCID 0000-0003-2621-7307

Funding

Mechanism of tubulin modification enzymesZIANS003163 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI ROLL-MECAK, ANTONINA · 2017 to 2025
$10.8M
6 · The paper itself

Abstract

Microtubule function is modulated by the tubulin code, diverse posttranslational modifications that are altered dynamically by writer and eraser enzymes

Indexed as

CarboxypeptidasesGlutamatesMicrotubulesTubulinAnimalsBinding SitesBrainCryoelectron MicroscopyCrystallography, X-RayHomeostasisHumansMagnetic Resonance SpectroscopyModels, MolecularProtein BindingSf9 CellsSubstrate SpecificityAGBL5 protein, humanCarboxypeptidasesGlutamatesTubulin

Identifiers

PMID39020174

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.