Evidence map›Paper›PMID 39020172›Full record

ArticleNature2024

Clonal inactivation of TERT impairs stem cell competition.

Kazuteru Hasegawa, Yang Zhao, Alina Garbuzov, M Ryan Corces, Patrick Neuhöfer, Victoria M Gillespie, Peggie Cheung, Julia A Belk, Yung-Hsin Huang, Yuning Wei and 3 more

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. circHERC1-A telomerase activator.Science advances · 2025
    Article
  7. Article
  8. A CanineAnimals : an open access journal from MDPI · 2025
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kazuteru HasegawaStanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
Yang ZhaoCenter for Personal Dynamic Regulomes, Stanford, CA, USA.
Alina GarbuzovStanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
M Ryan CorcesCenter for Personal Dynamic Regulomes, Stanford, CA, USA.
Patrick NeuhöferStanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-3936-383X
Victoria M GillespieNuclear Dynamics and Cancer Program, Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia, PA, USA.
Peggie CheungStanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
Julia A BelkDepartment of Computer Science, Stanford University, Stanford, CA, USA.ORCID 0000-0003-4724-6158
Yung-Hsin HuangCenter for Personal Dynamic Regulomes, Stanford, CA, USA.ORCID 0000-0002-5180-934X
Yuning WeiCenter for Personal Dynamic Regulomes, Stanford, CA, USA.
Lu ChenStanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-4571-7975
Howard Y ChangCenter for Personal Dynamic Regulomes, Stanford, CA, USA.ORCID 0000-0002-9459-4393
Steven E ArtandiStanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA. sartandi@stanford.edu.ORCID 0000-0001-5580-7512

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI MICHAEL KENNEY · 2007 to 2026
$71.4M
REVERSING CELLULAR IMMORTALITY IN CANCERR35CA197563 · NCI · STANFORD UNIVERSITY · PI ARTANDI, STEVEN E · 2015 to 2021
$6.4M
LncRNA mechanisms in cancerR35CA209919 · NCI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2016 to 2022
$6.4M
Determining the role of TCAB1 in shaping telomerase functionR01AG056575 · NIA · STANFORD UNIVERSITY · PI ARTANDI, STEVEN E · 2017 to 2021
$2.3M
Telomerase RNP Prisonbreaks from Phase-Separated Nuclear BodyR35GM150538 · NIGMS · RESEARCH INST OF FOX CHASE CAN CTR · PI Lu Chen · 2023 to 2026
$2.1M
NCI NIH HHS P30 CA124435NCI NIH HHS R35 CA197563NCI NIH HHS R35 CA209919NIA NIH HHS R01 AG056575NIGMS NIH HHS R35 GM150538
6 · The paper itself

Abstract

Telomerase is intimately associated with stem cells and cancer, because it catalytically elongates telomeres-nucleoprotein caps that protect chromosome ends

Indexed as

Cell CompetitionClone CellsStem CellsTelomeraseAgingAnimalsBiocatalysisCell DifferentiationCell LineageChromatinGene DeletionGenes, mycHomeostasisMaleMiceProto-Oncogene Proteins c-mycChromatinMyc protein, mouseProto-Oncogene Proteins c-mycTelomeraseTert protein, mouse

Identifiers

PMID39020172
PMCPMC11291281

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.