ArticleNature2024
Psilocybin desynchronizes the human brain.
2 registry-linked trialsAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 134 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed, 5 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT07306364 phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation
Psilocybin in Chronic Low Back Pain: An Integrative Study of Lab-Based Mechanisms and Real-World Physical Therapy Outcomes
NCT07582120 phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation
A Pilot Mechanistic Study of Psilocybin-Assisted Therapy as a Treatment for Depression
Who cites it
134 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- The Use of Psychedelics in the Treatment of Adult ADHD: A Systematic and Mechanistic Review.International journal of molecular sciences · 2026Pooled it
- Psilocybin in the treatment of eating disorders: a systematic review of the literature and registered clinical trials.Eating and weight disorders : EWD · 2025Pooled it
- What fMRI studies say about the nature of the psychedelic effect: a scoping review.Frontiers in neuroscience · 2025Pooled it
- Synergistic, multi-level understanding of psychedelics: three systematic reviews and meta-analyses of their pharmacology, neuroimaging and phenomenology.Translational psychiatry · 2024Pooled it
- Psychedelic-assisted therapy for treating anxiety, depression, and existential distress in people with life-threatening diseases.The Cochrane database of systematic reviews · 2024Pooled it
- Spatiotemporal mapping of brain organisation following the administration of 2C-B and psilocybin.Molecular psychiatry · 2026Trial
- A randomized clinical trial of repeated doses of psilocybin for the treatment of obsessive-compulsive disorder.Journal of psychopharmacology (Oxford, England) · 2026Trial
- Methylphenidate reorganizes cortical hierarchy through dopaminergic modulation.Nature communications · 2025Trial
- Large-scale brain connectivity changes following the administration of lysergic acid diethylamide, d-amphetamine, and 3,4-methylenedioxyamphetamine.Molecular psychiatry · 2025Trial
- LSD reconfigures cortical dynamics through faster brain rhythms and increased fractal dimension.Communications biology · 2026Article
- The entropic brain today.Brain : a journal of neurology · 2026Review
- Mescaline Alters Cerebellar Function, Global Connectivity, and Frequency-Selective Acoustic Gating: A BOLD fMRI Study in Awake Rats.Neuroscience bulletin · 2026Article
- Resetting the hippocampal buffer: a neurocognitive account of psychedelic therapy for anxiety-related psychopathology.Psychopharmacology · 2026Review
- Psychedelics do not always enhance cognitive flexibility: The potential role of time-varying effects on reward learning processes.Neuroscience and biobehavioral reviews · 2026Review
- Adolescent exposure to the psychedelic 25C-NBOMe in rats induces lasting competitive avoidance through disrupted hippocampal-prefrontal synchrony.Nature neuroscience · 2026Article
- Psilocybin enhances sociability only in altered behavioural state and does not need an awake experience to be effective.Nature communications · 2026Article
- Opposite network patterns of integration-segregation in psychedelic and sedated states of consciousness.Cell reports · 2026Article
- Impact of Psilocybin on Motor Function in Healthy Participants: A Phase 1, Randomised, Triple-Blind, Dose-Finding Study.CNS drugs · 2026Article
- Psychedelics align brain activity with context.Nature · 2026Article
- Psychedelics tune the brain to the environment.Nature · 2026Article
74 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Update of
Authors and funding
33 authors.
Joshua S SiegelDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA. jssiegel@wustl.edu.ORCID 0000-0002-5752-3641
Subha SubramanianDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Demetrius PerryDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Benjamin P KayDepartment of Neurology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0003-3628-8029
Evan M GordonMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-2276-5237
Timothy O LaumannDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-0428-427X
T Rick ReneauMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-0211-2482
Nicholas V MetcalfDepartment of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Ravi V ChackoDepartment of Emergency Medicine, Advocate Christ Health Care, Oak Lawn, IL, USA.
Caterina GrattonDepartment of Psychology, Florida State University, Tallahassee, FL, USA.ORCID 0000-0003-4607-7401
Christine HoranMiami VA Medical Center, Miami, FL, USA.
Samuel R KrimmelDepartment of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Joshua S ShimonyMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.
Julie A SchweigerDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Dean F WongMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0001-9343-8367
David A BenderDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Kristen M ScheidterDepartment of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Forrest I WhitingDepartment of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Jonah A Padawer-CurryDepartment of Biomedical Engineering, Washington University in St Louis, St Louis, MO, USA.
Russell T ShinoharaCenter for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA.
Yong ChenDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Julia MoserMasonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-6219-415X
Essa YacoubCenter for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA.
Steven M NelsonMasonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.
Luca VizioliCenter for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA.
Damien A FairMasonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-8602-393X
Eric J LenzeDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Robin Carhart-HarrisDepartment of Neurology, University of California, San Francisco, CA, USA.ORCID 0000-0002-6062-7150
Charles L RaisonUsona Institute, Fitchburg, WI, USA.
Marcus E RaichleDepartment of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Abraham Z SnyderDepartment of Neurology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-3379-9627
Ginger E Nicol *Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Nico U F Dosenbach *Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-6876-7078
Funding
ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7MABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5MAdolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5MABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7MProspective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2MABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7MABCD-USA Consortium: Research ProjectU01DA041106 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mary M Heitzeg, Chandra Sekhar Sripada · 2015 to 2026
$24.9MFIU-ABCD: Pathways and Mechanisms to Addiction in the Latino Youth of South FloridaU01DA041156 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI Raul Gonzalez, Angela R Laird · 2015 to 2026
$22.8MABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3MABCD-USA: NYC Research ProjectU01DA041174 · NIDA · YALE UNIVERSITY · PI Arielle Ryan Baskin-Sommers, Betty J Casey · 2015 to 2026
$19.7MAdolescent Brain Cognitive Development (ABCD) Prospective Research in Studies of Maturation (PRISM) ConsortiumU01DA041117 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LINDA CHANG, THOMAS M ERNST · 2015 to 2026
$19.5M15/21 ABCD-USA Consortium: Research Project Site at LIBRU01DA050989 · NIDA · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI ROBIN L AUPPERLE, MARTIN P. PAULUS · 2020 to 2026
$14.7MNIDA NIH HHS T32 DA007261NIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041025NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041093NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U01 DA050987NIDA NIH HHS U01 DA050988NIDA NIH HHS U01 DA050989NIDA NIH HHS U01 DA051016NIDA NIH HHS U01 DA051018NIDA NIH HHS U01 DA051037NIDA NIH HHS U01 DA051038NIDA NIH HHS U01 DA051039NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147NIMH NIH HHS K99 MH129616NIMH NIH HHS R00 MH129616NIMH NIH HHS R01 MH096773NIMH NIH HHS R01 MH118370NIMH NIH HHS R25 MH112473NIMH NIH HHS R44 MH121276NIMH NIH HHS R44 MH122066NIMH NIH HHS R44 MH124567NINDS NIH HHS K23 NS088590NINDS NIH HHS K23 NS123345NINDS NIH HHS R01 NS124738NINDS NIH HHS R44 NS129521NINDS NIH HHS T32 NS121881
Abstract
A single dose of psilocybin, a psychedelic that acutely causes distortions of space-time perception and ego dissolution, produces rapid and persistent therapeutic effects in human clinical trials
Indexed as
BrainHallucinogensNerve NetPsilocybinAdolescentAdultBrain MappingDefault Mode NetworkEgoFemaleHealthy VolunteersHippocampusHumansMagnetic Resonance ImagingMaleMethylphenidateHallucinogensMethylphenidatePsilocybin
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
NCT07306364ClinicalTrials.gov
NCT07582120ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.